Background BCG vaccination provides incomplete protection against tuberculosis in infants.
A new vaccine, modified Vaccinia Ankara virus expressing antigen 85A (MVA85A), was …

Background Identification of blood biomarkers that prospectively predict progression of
Mycobacterium tuberculosis infection to tuberculosis disease might lead to interventions that …

Background Recent Mycobacterium tuberculosis infection confers a predisposition to the
development of tuberculosis disease, the leading killer among global infectious diseases. H4:…

We investigated whether the proinflammatory T cell cytokines IL-17 and IL-22 are induced by
human mycobacterial infection. Remarkably,> 20% of specific cytokine-producing CD4+ T …

The adaptive immune response mediated by T cells is critical for control of Mycobacterium
tuberculosis (M. tuberculosis) infection in humans. However, the M. tuberculosis antigens and …

Rationale: Immunogenicity of new tuberculosis (TB) vaccines is commonly assessed by
measuring the frequency and cytokine expression profile of T cells. Objectives: We tested …

Rapid diagnosis of active Mycobacterium tuberculosis (Mtb) infection remains a clinical and
laboratory challenge. We have analyzed the cytokine profile (interferon-γ (IFN-γ), tumor …

High Ag load in chronic viral infections has been associated with impairment of Ag-specific
T cell responses; however, the relationship between Ag load in chronic Mycobacterium …

Rationale: AERAS-402 is a novel tuberculosis vaccine designed to boost immunity primed by
bacillus Calmette-Guérin (BCG), the only licensed vaccine. Objectives: We investigated the …

The immune response to vaccination with bacillus Calmette-Guérin (BCG), the only
tuberculosis vaccine available, has not been fully characterized. We used multiparameter flow …