The pathogenesis of chronic obstructive pulmonary disease (COPD) remains unclear, but
involves loss of alveolar surface area (emphysema) and airway inflammation (bronchitis) as …

Persistent inflammation within the respiratory tract underlies the pathogenesis of numerous
chronic pulmonary diseases including chronic obstructive pulmonary disease, asthma and …

Autophagy is a dynamic process by which cytosolic material, including organelles, proteins,
and pathogens, are sequestered into membrane vesicles called autophagosomes, and then …

Copper serves as a co-factor for a host of metalloenzymes that contribute to malignant
progression. The orally bioavailable copper chelating agent tetrathiomolybdate (TM) has been …

Chronic obstructive pulmonary disease (COPD) involves aberrant airway inflammatory
responses to cigarette smoke (CS) that are associated with epithelial cell dysfunction, cilia …

Mitochondria are a distinguishing feature of eukaryotic cells. Best known for their critical
function in energy production via oxidative phosphorylation (OXPHOS), mitochondria are …

Chronic obstructive pulmonary disease (COPD) is linked to both cigarette smoking and genetic
determinants. We have previously identified iron-responsive element–binding protein 2 (…

The synthesis and photophysical and biological investigation of Ru(II)-polypyridyl stabilized
water-soluble, luminescent gold nanoparticles (AuNPs) are described. These structures bind …

Important cellular processes such as inflammation, apoptosis, differentiation, and proliferation
confer critical roles in the pathogenesis of human diseases. In the past decade, an …

Mitochondria are an iconic distinguishing feature of eukaryotic cells. Mitochondria encompass
an active organellar network that fuses, divides, and directs a myriad of vital biological …