Tuberculosis poses a significant threat to mankind. Multidrug-resistant strains are on the rise,
and Mycobacterium tuberculosis infection is often associated with human …

… Stefan H. E Kaufmann … Copyright: © 2007 Schaible and Kaufmann. This is an open-access
article distributed under the terms of the Creative Commons Attribution License, which …

B lymphocytes have critical roles as positive and negative regulators of immunity. Their
inhibitory function has been associated primarily with interleukin 10 (IL-10) because B-cell-…

Heat shock proteins (HSPs) or stress proteins are produced by prokaryotic and eukaryotic
cells in response to a variety of insults. After this original definition, it has become incre Jsingly …

The use of iron as a cofactor in basic metabolic pathways is essential to both pathogenic
microorganisms and their hosts. It is also a pivotal component of the innate immune response …

Tuberculosis (TB) remains a major health threat, killing nearly 2 million individuals around
this globe, annually. The only vaccine, developed almost a century ago, provides limited …

Background Identification of blood biomarkers that prospectively predict progression of
Mycobacterium tuberculosis infection to tuberculosis disease might lead to interventions that …

Increased synthesis of heat shock proteins (hsp) occurs in prokaryotic and eukaryotic cells
when they are exposed to stress. By increasing their hsp content, cells protect themselves …

The tuberculosis vaccine Mycobacterium bovis bacille Calmette-Guérin (BCG) was equipped
with the membrane-perforating listeriolysin (Hly) of Listeria monocytogenes, which was …

Protective immunity against Mycobacterium tuberculosis involves major histocompatibility
complex class I (MHC-I)- and CD1-restricted CD8 T cells, but the mechanisms underlying …