Variable β-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment

T Brabletz, A Jung, S Reu, M Porzner… - Proceedings of the …, 2001 - National Acad Sciences
Invasion and dissemination of well-differentiated carcinomas are often associated with loss
of epithelial differentiation and gain of mesenchyme-like capabilities of the tumor cells at the …

Consistent success in life-supporting porcine cardiac xenotransplantation

…, K Klett, R Hinkel, C Kupatt, A Falkenau, S Reu… - Nature, 2018 - nature.com
Heart transplantation is the only cure for patients with terminal cardiac failure, but the supply
of allogeneic donor organs falls far short of the clinical need 1, 2, 3. Xenotransplantation of …

[HTML][HTML] Harmonized PD-L1 immunohistochemistry for pulmonary squamous-cell and adenocarcinomas

…, M Dietel, LC Heukamp, K Jöhrens, T Kirchner, S Reu… - Modern Pathology, 2016 - Elsevier
Immunohistochemistry of the PD-L1 protein may be predictive for anti-PD-1 and anti-PD-L1
immunotherapy in pulmonary adenocarcinoma and in clinically unselected cohorts of so-…

Spatial density and distribution of tumor-associated macrophages predict survival in non–small cell lung carcinoma

X Zheng, A Weigert, S Reu, S Guenther, S Mansouri… - Cancer research, 2020 - AACR
This study underlines the significance of the density, spatial distribution, and gene
expression of TAM phenotypes as prognostic factors for overall survival in lung cancer. …

Lung disease caused by ABCA3 mutations

C Kröner, T Wittmann, S Reu, V Teusch, M Klemme… - Thorax, 2017 - thorax.bmj.com
Background Knowledge about the clinical spectrum of lung disease caused by variations in
the ATP binding cassette subfamily A member 3 (ABCA3) gene is limited. Here we describe …

[HTML][HTML] Up and downregulation of p16Ink4a expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer

L Kriegl, J Neumann, M Vieth, FR Greten, S Reu… - Modern Pathology, 2011 - Elsevier
P16 Ink4a is an important factor in carcinogenesis and its expression can be linked to
oncogene-induced senescence. Oncogene-induced senescence is characterized by growth arrest …

Interlaboratory concordance of PD‐L1 immunohistochemistry for non‐small‐cell lung cancer

…, T Kirchner, F Lasitschka, I Petersen, S Reu… - …, 2018 - Wiley Online Library
Aims Programmed death ligand 1 ( PD ‐L1) immunohistochemistry has become a mandatory
diagnostic test in the treatment of lung cancer. Several research initiatives have started to …

Comparative study of the sensitivity of different diagnostic methods for the laboratory diagnosis of Buruli ulcer disease

…, E Klutse, P Agbenorku, A Schipf, S Reu… - Clinical Infectious …, 2009 - academic.oup.com
Background. Several diagnostic laboratory methods are available for case confirmation of
Buruli ulcer disease. This study assessed the sensitivity of various diagnostic tests in relation …

Genotype alone does not predict the clinical course of SFTPC deficiency in paediatric patients

C Kröner, S Reu, V Teusch, A Schams… - European …, 2015 - Eur Respiratory Soc
Patients with interstitial lung disease due to surfactant protein C (SFTPC) mutations are rare
and not well characterised. We report on all subjects collected over a 15-year period in the …

International management platform for children's interstitial lung disease (chILD-EU)

M Griese, E Seidl, M Hengst, S Reu, H Rock… - Thorax, 2018 - thorax.bmj.com
Background Children’s interstitial lung diseases (chILD) cover many rare entities, frequently
not diagnosed or studied in detail. There is a great need for specialised advice and for …