Rationale: Eradication and suppression of Pseudomonas aeruginosa is a key priority in national
guidelines for bronchiectasis and is a major focus of drug development and clinical trials…

Rationale: Sputum neutrophil elastase and serum desmosine, which is a linked marker of
endogenous elastin degradation, are possible biomarkers of disease severity and progression …

Background Patients with bronchiectasis often have concurrent comorbidities, but the nature,
prevalence, and impact of these comorbidities on disease severity and outcome are poorly …

Background Bronchiectasis is predominantly a neutrophilic inflammatory disease. There are
no established therapies that directly target neutrophilic inflammation because little is …

Introduction Bronchiectasis is a multidimensional disease associated with substantial morbidity
and mortality. Two disease-specific clinical prediction tools have been developed, the …

Background The sputum microbiome has a potential role in disease phenotyping and risk
stratification in chronic obstructive pulmonary disease (COPD), but few large longitudinal …

Background Infection is a key component of bronchiectasis pathophysiology. Characterisation
of the microbiome offers a higher degree of sensitivity and resolution than does traditional …

A correlation was found between the levels of cyanide production and of tannins and the
palatability of bracken Pteridium aquilinum L. Kuhn to sheep and deer and to the phytophagous …

Rationale: The principal underlying inhaled antibiotic treatment in bronchiectasis is that
airway bacterial load drives inflammation, and therefore antibiotic treatment will reduce …

Rationale: PZP (pregnancy zone protein) is a broad-spectrum immunosuppressive protein
believed to suppress T-cell function during pregnancy to prevent fetal rejection. It has not …