Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play important
roles in immunity, cell growth, and cell signaling. In excess, however, ROS are lethal to …

Acquiring the capability to access structurally complex and diverse molecules through simple
starting substrates has been one of the underlying principles of chemical research. These …

LPS stimulates monocytes/macrophages through the activation of signaling events that
modulate the production of inflammatory cytokines. Apigenin, a flavonoid abundantly found in …

Bacterial lung diseases are a major cause of morbidity and mortality both in immunocompromised
and in immunocompetent individuals. Neutrophil accumulation, a pathological …

In our previous studies, we have shown that benzyl isothiocyanate (BITC) inhibits the
growth of human pancreatic cancer cells by inducing apoptosis. In the present study, we …

Reactive oxygen metabolites (ROMs), including superoxide anion (O 2 ·− ), hydrogen peroxide
(H 2 O 2 ) and hydroxyl radical ( · OH), play an important role in carcinogenesis. There …

Quinoline is a heterocyclic scaffold of paramount importance to human race. The utility of
quinoline derivatives in the areas of medicine, food, catalyst, dye, materials, refineries and …

Caspase-3 is an essential executioner of apoptosis responsible for regulating many important
cellular processes, among them the number of circulating monocytes, central players in …

Reactive oxygen species (ROS) are pervasive signaling molecules in biological systems. In
humans, a lack of ROS causes chronic and extreme bacterial infections, while uncontrolled …

Bacterial flagellin is critical to mediate NLRC4 inflammasome-dependent caspase-1 activation.
However, Shigella flexneri, a nonflagellated bacterium, and a flagellin (fliC) knockout …