[HTML][HTML] Developments in lung transplantation over the past decade

SC van der Mark, RAS Hoek… - European Respiratory …, 2020 - Eur Respiratory Soc
With an improved median survival of 6.2 years, lung transplantation has become an
increasingly acceptable treatment option for end-stage lung disease. Besides survival benefit, …

[HTML][HTML] Duration and key determinants of infectious virus shedding in hospitalized patients with coronavirus disease-2019 (COVID-19)

…, DA Gommers, JJ Cornelissen, RAS Hoek… - Nature …, 2021 - nature.com
Key questions in COVID-19 are the duration and determinants of infectious virus shedding.
Here, we report that infectious virus shedding is detected by virus cultures in 23 of the 129 …

Shedding of infectious virus in hospitalized patients with coronavirus disease-2019 (COVID-19): duration and key determinants

…, H Endeman, DA Gommers, JJ Cornelissen, RAS Hoek… - MedRxiv, 2020 - medrxiv.org
Background Long-term shedding of viral RNA in COVID-19 prevents timely discharge from
the hospital or de-escalation of infection prevention and control practices. Key questions are …

Clinical characteristics and outcomes of immunocompromised patients with coronavirus disease 2019 caused by the omicron variant: a prospective, observational …

SRK Malahe, RAS Hoek, VASH Dalm… - Clinical Infectious …, 2023 - academic.oup.com
Background Illness after infection with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Omicron variant is less severe compared with previous variants. Data on the …

COVID‐19 in solid organ transplant recipients: a single‐center experience

RAS Hoek, OC Manintveld, MGH Betjes… - Transplant …, 2020 - Wiley Online Library
Solid organ transplant (SOT) recipients may be at risk for severe COVID‐19. Data on the
clinical course of COVID‐19 in immunosuppressed patients are limited, and the effective …

[HTML][HTML] Current perspectives on the management of herpesvirus infections in solid organ transplant recipients

…, JJA van Kampen, OC Manintveld, RAS Hoek… - Viruses, 2023 - mdpi.com
Solid organ transplant recipients (SOTRs) are at high risk of human herpesvirus (HHV)-related
morbidity and mortality due to the use of immunosuppressive therapy. We aim to increase …

[HTML][HTML] Aspergillus in Critically Ill COVID-19 Patients: A Scoping Review

E Yusuf, L Seghers, RAS Hoek… - Journal of Clinical …, 2021 - mdpi.com
Several reports have been published on Aspergillus findings in COVID-19 patients leading
to a proposition of new disease entity COVID-19-associated pulmonary aspergillosis. This …

Incidence of viral respiratory pathogens causing exacerbations in adult cystic fibrosis patients

RAS Hoek, MS Paats, SD Pas, M Bakker… - … journal of infectious …, 2013 - Taylor & Francis
Respiratory infections caused by respiratory viruses are common in paediatric cystic fibrosis
(CF) patients and are associated with increased morbidity. There is only little data on the …

High levels of neutrophil extracellular traps persist in the lower respiratory tract of critically ill patients with coronavirus disease 2019

…, JH von der Thusen, L Guo, RAS Hoek… - The Journal of …, 2021 - academic.oup.com
Lower respiratory tract (LRT) disease induced by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) can deteriorate to acute respiratory distress syndrome (ARDS). …

[HTML][HTML] Enhanced Bruton's tyrosine kinase in B-cells and autoreactive IgA in patients with idiopathic pulmonary fibrosis

…, JH von der Thusen, B van den Blink, RAS Hoek… - Respiratory …, 2019 - Springer
Rationale Idiopathic Pulmonary Fibrosis (IPF) is thought to be triggered by repeated alveolar
epithelial cell injury. Current evidence suggests that aberrant immune activation may …