User profiles for R. Saggar

Rajan Saggar

University of California Los Angeles
Verified email at mednet.ucla.edu
Cited by 8426

Pulmonary vascular hemodynamic response to exercise in cardiopulmonary diseases

GD Lewis, E Bossone, R Naeije, E Grünig, R Saggar… - Circulation, 2013 - Am Heart Assoc
… where R 0 is PVR and Q is pulmonary blood flow. The distensibility coefficient α defines how
much resistance vessel diameters increase as a percent of baseline per mmHg distending …

Exercise-induced pulmonary hypertension: physiological basis and methodological concerns

…, BP Dhakal, R Saggar, R Saggar… - American journal of …, 2013 - atsjournals.org
… where R 0 is total pulmonary vascular resistance. This equation is more complicated than
the traditional PVR equation, and an α of 2%/mm Hg pressure may not seem substantial. We …

Diagnosis and treatment of pulmonary sarcoidosis: a review

…, F Shaikh, FG Abtin, MC Fishbein, SS Weigt, R Saggar… - Jama, 2022 - jamanetwork.com
Importance Sarcoidosis is an inflammatory granulomatous disease of unknown cause that
affects an estimated 2 to 160 people per 100 000 worldwide and can involve virtually any …

[HTML][HTML] Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension

…, SO Vargas, R Saggar, R Saggar… - The Journal of …, 2016 - Am Soc Clin Investig
Dysregulation of vascular stiffness and cellular metabolism occurs early in pulmonary
hypertension (PH). However, the mechanisms by which biophysical properties of the vascular …

Right ventricular dysfunction in systemic sclerosis–associated pulmonary arterial hypertension

…, SD Russell, R Saggar, R Saggar… - Circulation: Heart …, 2013 - Am Heart Assoc
… decline for any corresponding R PA , shifting the R PA -C PA … principally on factors that
influence mean R PA . The small but … Our prior analysis also showed no change in the R PA -C PA …

[HTML][HTML] Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension

…, A Hale, B Bhat, R Saggar, R Saggar… - The Journal of …, 2014 - Am Soc Clin Investig
Development of the vascular disease pulmonary hypertension (PH) involves disparate
molecular pathways that span multiple cell types. MicroRNAs (miRNAs) may coordinately …

Tuberculous osteomyelitis

…, S Dogra, RR Saggar, R Sharma - The Journal of Bone …, 1997 - boneandjoint.org.uk
Tuberculous osteomyelitis which does not involve a joint is uncommon and may fail to be
diagnosed by an orthopaedic surgeon. We treated 28 lesions of tuberculous osteomyelitis in …

An official European Respiratory Society statement: pulmonary haemodynamics during exercise

…, A Peacock, S Rosenkranz, R Saggar… - European …, 2017 - Eur Respiratory Soc
There is growing recognition of the clinical importance of pulmonary haemodynamics during
exercise, but several questions remain to be elucidated. The goal of this statement is to …

[PDF][PDF] Matrix remodeling promotes pulmonary hypertension through feedback mechanoactivation of the YAP/TAZ-miR-130/301 circuit

…, YY Zhang, BB Graham, R Kumar, R Saggar, R Saggar… - Cell reports, 2015 - cell.com
Pulmonary hypertension (PH) is a deadly vascular disease with enigmatic molecular origins.
We found that vascular extracellular matrix (ECM) remodeling and stiffening are early and …

[HTML][HTML] Right ventricular systolic pressure by echocardiography as a predictor of pulmonary hypertension in idiopathic pulmonary fibrosis

SD Nathan, OA Shlobin, SD Barnett, R Saggar… - Respiratory …, 2008 - Elsevier
RATIONALE: Pulmonary hypertension (PH) commonly complicates the course of patients with
idiopathic pulmonary fibrosis (IPF). It has a significant impact on outcomes and is, therefore…