Conventional wisdom is that chronic liver disease is an acquired bleeding disorder.
However, the imbalance between procoagulant and anticoagulant activities can also lead to …

The role played by coagulation defects in the occurrence of bleeding in cirrhosis is still
unclear. This is partly due to the lack of tests that truly reflect the balance of procoagulant and …

I the enhancement of blood clotting associated with stress was caused by the liberation of
adrenaline in plasma. 6, 7 In 1957, N 1977 DESMOPRESSIN (1-deamino-8-D-arginine …

We investigated the relation between clotting factor concentration, the parameters of the
thrombin generation curve (the thrombogram) and the severity of clinically observed bleeding in …

When bleeding is the consequence of a specific defect of hemostasis, the goal of treatment
is to correct the defect. A typical example is the replacement of factor VIII by transfusion in …

Since the early 1980s there has been an explosion of new knowledge, with the identification
first of protein C (PC) deficiency’and then of protein S (PS) as additional causes of inherited …

Background Idiopathic cerebral-vein thrombosis can cause serious neurologic disability. We
evaluated risk factors for this disorder, including genetic risk factors (mutations in the genes …

BACKGROUND The blood coagulation system is activated in the acute phase of unstable
angina and acute myocardial infarction. However, it remains unclear whether augmented …

In a randomized double-blind cross-over trial we gave either 1-deamino-8-D-arginine
vasopressin or placebo to 12 patients with uremia, hemorrhagic tendencies, and prolonged …

Background Point mutations in the factor V gene (factor V Leiden) and the prothrombin
gene (the substitution of A for G at position 20210) are the most common causes of inherited …