User profiles for Pia Abel zur Wiesch
Pia Abel zur WieschAssociate Professor/ Early Career Chair, Penn State University Verified email at psu.edu Cited by 2228 |
Antagonism between bacteriostatic and bactericidal antibiotics is prevalent
Combination therapy is rarely used to counter the evolution of resistance in bacterial infections.
Expansion of the use of combination therapy requires knowledge of how drugs interact at …
Expansion of the use of combination therapy requires knowledge of how drugs interact at …
Population biological principles of drug-resistance evolution in infectious diseases
The emergence of resistant pathogens in response to selection pressure by drugs and their
possible disappearance when drug use is discontinued are evolutionary processes common …
possible disappearance when drug use is discontinued are evolutionary processes common …
[HTML][HTML] Bi-modal Distribution of the Second Messenger c-di-GMP Controls Cell Fate and Asymmetry during the Caulobacter Cell Cycle
…, M Nicollier, I Hug, V Kaever, P Abel zur Wiesch… - PLoS …, 2013 - journals.plos.org
Many bacteria mediate important life-style decisions by varying levels of the second
messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular …
messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular …
[HTML][HTML] Analysis of bottlenecks in experimental models of infection
S Abel, P Abel zur Wiesch, BM Davis… - PLoS …, 2015 - journals.plos.org
The metaphor of a bottleneck has been used in a variety of fields to describe the critical
constraints that limit a system’s performance or capacity. In biology, particularly in studies of …
constraints that limit a system’s performance or capacity. In biology, particularly in studies of …
Genetic analysis of Vibrio parahaemolyticus intestinal colonization
…, CJ Blondel, P Abel zur Wiesch… - Proceedings of the …, 2016 - National Acad Sciences
Vibrio parahaemolyticus is the most common cause of seafood-borne gastroenteritis worldwide
and a blight on global aquaculture. This organism requires a horizontally acquired type …
and a blight on global aquaculture. This organism requires a horizontally acquired type …
The path of least resistance: aggressive or moderate treatment?
…, EY Klein, P Abel zur Wiesch… - … of the Royal …, 2014 - royalsocietypublishing.org
The evolution of resistance to antimicrobial chemotherapy is a major and growing cause of
human mortality and morbidity. Comparatively little attention has been paid to how different …
human mortality and morbidity. Comparatively little attention has been paid to how different …
Sequence tag–based analysis of microbial population dynamics
We describe sequence tag–based analysis of microbial populations (STAMP) for characterization
of pathogen population dynamics during infection. STAMP analyzes the frequency …
of pathogen population dynamics during infection. STAMP analyzes the frequency …
[HTML][HTML] Cycling empirical antibiotic therapy in hospitals: meta-analysis and models
The rise of resistance together with the shortage of new broad-spectrum antibiotics
underlines the urgency of optimizing the use of available drugs to minimize disease burden. …
underlines the urgency of optimizing the use of available drugs to minimize disease burden. …
[HTML][HTML] Smear positivity in paediatric and adult tuberculosis: systematic review and meta-analysis
A Kunkel, P Abel zur Wiesch, RR Nathavitharana… - BMC infectious …, 2016 - Springer
Background Tuberculosis (TB) diagnosis continues to rely on sputum smear microscopy in
many settings. We conducted a meta-analysis to estimate the percentage of children and …
many settings. We conducted a meta-analysis to estimate the percentage of children and …
Classic reaction kinetics can explain complex patterns of antibiotic action
P Abel Zur Wiesch, S Abel, S Gkotzis… - Science translational …, 2015 - science.org
Finding optimal dosing strategies for treating bacterial infections is extremely difficult, and
improving therapy requires costly and time-intensive experiments. To date, an incomplete …
improving therapy requires costly and time-intensive experiments. To date, an incomplete …