Combination therapy is rarely used to counter the evolution of resistance in bacterial infections.
Expansion of the use of combination therapy requires knowledge of how drugs interact at …

The emergence of resistant pathogens in response to selection pressure by drugs and their
possible disappearance when drug use is discontinued are evolutionary processes common …

Many bacteria mediate important life-style decisions by varying levels of the second
messenger c-di-GMP. Behavioral transitions result from the coordination of complex cellular …

The metaphor of a bottleneck has been used in a variety of fields to describe the critical
constraints that limit a system’s performance or capacity. In biology, particularly in studies of …

Vibrio parahaemolyticus is the most common cause of seafood-borne gastroenteritis worldwide
and a blight on global aquaculture. This organism requires a horizontally acquired type …

The evolution of resistance to antimicrobial chemotherapy is a major and growing cause of
human mortality and morbidity. Comparatively little attention has been paid to how different …

We describe sequence tag–based analysis of microbial populations (STAMP) for characterization
of pathogen population dynamics during infection. STAMP analyzes the frequency …

The rise of resistance together with the shortage of new broad-spectrum antibiotics
underlines the urgency of optimizing the use of available drugs to minimize disease burden. …

Background Tuberculosis (TB) diagnosis continues to rely on sputum smear microscopy in
many settings. We conducted a meta-analysis to estimate the percentage of children and …

Finding optimal dosing strategies for treating bacterial infections is extremely difficult, and
improving therapy requires costly and time-intensive experiments. To date, an incomplete …