Mammalian cells respond to stress by accumulating or activating a set of highly conserved
proteins known as heat-shock proteins (HSPs). Several of these proteins interfere negatively …

An ever-increasing number of drugs can reproduce variegated patterns of naturally occurring
interstitial lung disease (ILD), including most forms of interstitial pneumonias, alveolar …

Epithelial mesenchymal transition (EMT), a process involved in many growth and repair
functions, has been identified in the peritoneal tissues of patients who undergo peritoneal …

Transient adenovirus-mediated gene transfer of IL-1β (AdIL-1β), a proinflammatory cytokine,
induces marked inflammation and severe and progressive fibrosis in rat lungs. This is …

Background To date, influenza epidemics have been considered suitable for use as a model
for the COVID-19 epidemic, given that they are respiratory diseases with similar modes of …

The selection of pharmacotherapy for patients with allergic rhinitis aims to control the disease
and depends on many factors. Grading of Recommendations Assessment, Development …

Transforming growth factor-β1 plays a key role in the pathogenesis of pulmonary fibrosis,
mediating extracellular matrix (ECM) gene expression through a series of intracellular …

Pulmonary fibrosis is characterized by chronic scar formation and deposition of extracellular
matrix, resulting in impaired lung function and respiratory failure. Idiopathic pulmonary …

Background Benralizumab is an interleukin-5 receptor α-directed cytolytic monoclonal
antibody that has been shown to safely reduce exacerbations and improve lung function for …

Background Since 2009, IPF patients across Europe are recruited into the eurIPFreg, providing
epidemiological data and biomaterials for translational research. Methods The registry …