User profiles for Patricia Goggin

Patricia Goggin

Electron Microscopist, Biomedical Imaging Unit
Verified email at soton.ac.uk
Cited by 1296

Process of care failures in invasive cervical cancer: systematic review and meta-analysis

AR Spence, P Goggin, EL Franco - Preventive medicine, 2007 - Elsevier
OBJECTIVE: As invasive cervical cancer is preventable when screening and treatment of
pre-invasive lesions are timely and appropriate, several past studies attempted to enumerate …

Mutations in CCDC39 and CCDC40 are the Major Cause of Primary Ciliary Dyskinesia with Axonemal Disorganization and Absent Inner Dynein Arms

…, T Taylor‐Cox, A Dewar, C Jackson, P Goggin… - Human …, 2013 - Wiley Online Library
Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder caused by cilia and
sperm dysmotility. About 12% of cases show perturbed 9+2 microtubule cilia structure and …

[HTML][HTML] Culture of primary ciliary dyskinesia epithelial cells at air-liquid interface can alter ciliary phenotype but remains a robust and informative diagnostic aid

…, JL Coles, G Williams, A Rutman, PM Goggin… - PloS one, 2014 - journals.plos.org
Background The diagnosis of primary ciliary dyskinesia (PCD) requires the analysis of ciliary
function and ultrastructure. Diagnosis can be complicated by secondary effects on cilia …

International consensus guideline for reporting transmission electron microscopy results in the diagnosis of primary ciliary dyskinesia (BEAT PCD TEM Criteria)

…, MM De Santi, P Goggin… - European …, 2020 - Eur Respiratory Soc
Primary ciliary dyskinesia (PCD) is a heterogeneous genetic condition. European and North
American diagnostic guidelines recommend transmission electron microscopy (TEM) as …

Accuracy of diagnostic testing in primary ciliary dyskinesia

…, L Behan, SA Collins, PM Goggin… - European …, 2016 - Eur Respiratory Soc
Diagnosis of primary ciliary dyskinesia (PCD) lacks a “gold standard” test and is therefore
based on combinations of tests including nasal nitric oxide (nNO), high-speed video …

High prevalence of CCDC103 p. His154Pro mutation causing primary ciliary dyskinesia disrupts protein oligomerisation and is associated with normal diagnostic …

…, AV Rogers, A Rutman, CL Jackson, P Goggin… - Thorax, 2018 - thorax.bmj.com
Rationale Primary ciliary dyskinesia is a genetically heterogeneous inherited condition
characterised by progressive lung disease arising from abnormal cilia function. Approximately …

Risk factors for situs defects and congenital heart disease in primary ciliary dyskinesia

…, A Rutman, S Ollosson, CL Jackson, P Goggin… - Thorax, 2019 - thorax.bmj.com
Primary ciliary dyskinesia (PCD) is associated with abnormal organ positioning (situs) and
congenital heart disease (CHD). This study investigated genotype–phenotype associations in …

Static respiratory cilia associated with mutations in Dnahc11/DNAH11: A mouse model of PCD

JS Lucas, EC Adam, PM Goggin, CL Jackson… - Human …, 2012 - Wiley Online Library
Primary ciliary dyskinesia (PCD) is an inherited disorder causing significant upper and lower
respiratory tract morbidity and impaired fertility. Half of PCD patients show abnormal situs. …

Clinical utility of NGS diagnosis and disease stratification in a multiethnic primary ciliary dyskinesia cohort

…, S Ollosson, C Jackson, P Goggin… - Journal of Medical …, 2020 - jmg.bmj.com
Background Primary ciliary dyskinesia (PCD), a genetically heterogeneous condition enriched
in some consanguineous populations, results from recessive mutations affecting cilia …

[HTML][HTML] Whole genome sequencing in the diagnosis of primary ciliary dyskinesia

…, P Goggin… - BMC Medical …, 2021 - Springer
Background It is estimated that 1–13% of cases of bronchiectasis in adults globally are
attributable to primary ciliary dyskinesia (PCD) but many adult patients with bronchiectasis have …