Epidemiology of COPD
C Raherison, PO Girodet - European Respiratory Review, 2009 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is responsible for early mortality, high death
rates and significant cost to health systems. The projection for 2020 indicates that COPD will …
rates and significant cost to health systems. The projection for 2020 indicates that COPD will …
Airway remodeling in asthma: new mechanisms and potential for pharmacological intervention
PO Girodet, A Ozier, I Bara, JMT de Lara… - Pharmacology & …, 2011 - Elsevier
The chronic inflammatory response within the airways of asthmatics is associated with structural
changes termed airway remodeling. This remodeling process is a key feature of severe …
changes termed airway remodeling. This remodeling process is a key feature of severe …
[HTML][HTML] The pivotal role of airway smooth muscle in asthma pathophysiology
A Ozier, B Allard, I Bara, PO Girodet, T Trian… - Journal of …, 2011 - hindawi.com
Asthma is characterized by the association of airway hyperresponsiveness (AHR), inflammation,
and remodelling. The aim of the present article is to review the pivotal role of airway …
and remodelling. The aim of the present article is to review the pivotal role of airway …
Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma
…, H Begueret, R Rossignol, PO Girodet… - The Journal of …, 2007 - rupress.org
Asthma and chronic obstructive pulmonary disease (COPD) are characterized by different
patterns of airway remodeling, which all include an increased mass of bronchial smooth …
patterns of airway remodeling, which all include an increased mass of bronchial smooth …
Chronic obstructive pulmonary disease exacerbation and inhaler device handling: real-life assessment of 2935 patients
…, R Lassalle, N Moore, PO Girodet - European …, 2017 - Eur Respiratory Soc
Acute exacerbations of chronic obstructive pulmonary disease (COPD) can be prevented by
inhaled treatment. Errors in inhaler handling, not taken into account in clinical trials, could …
inhaled treatment. Errors in inhaler handling, not taken into account in clinical trials, could …
A proof-of-concept, randomized, controlled trial of omalizumab in patients with severe, difficult-to-control, nonatopic asthma
…, LJ Couderc, A Didier, DS O'Callaghan, PO Girodet… - Chest, 2013 - Elsevier
Background While up to 50% of patients with severe asthma have no evidence of allergy,
IgE has been linked to asthma, irrespective of atopic status. Omalizumab, an anti-IgE …
IgE has been linked to asthma, irrespective of atopic status. Omalizumab, an anti-IgE …
Onset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma …
…, Y Douadi, S Fry, G Garcia, PO Girodet… - The lancet respiratory …, 2021 - thelancet.com
Background ANDHI was done to assess the efficacy of benralizumab, including onset of effect
and impact on health-related quality of life (HRQOL), exacerbation rate, lung function, and …
and impact on health-related quality of life (HRQOL), exacerbation rate, lung function, and …
Alternative macrophage activation is increased in asthma
PO Girodet, D Nguyen, JD Mancini… - American journal of …, 2016 - atsjournals.org
The immune responses of type 2 T helper cells (Th2) play an important role in asthma and
promote the differentiation of alternatively activated (M2) macrophages. M2 macrophages …
promote the differentiation of alternatively activated (M2) macrophages. M2 macrophages …
[HTML][HTML] Efficacy, safety, and immunogenicity of a booster regimen of Ad26. COV2. S vaccine against COVID-19 (ENSEMBLE2): results of a randomised, double-blind …
…, A Gibson, C Gillet, N Girerd, PO Girodet… - The Lancet Infectious …, 2022 - thelancet.com
Background Despite the availability of effective vaccines against COVID-19, booster
vaccinations are needed to maintain vaccine-induced protection against variant strains and …
vaccinations are needed to maintain vaccine-induced protection against variant strains and …
Fraktalkine produced by airway smooth muscle cells contributes to mast cell recruitment in asthma
A El-Shazly, P Berger, PO Girodet… - The Journal of …, 2006 - journals.aai.org
Human airway smooth muscle cells (HASMC) secrete fractalkine (FKN), a chemokine the
concentration of which is increased in asthmatic patients. HASMC also induce mast cell …
concentration of which is increased in asthmatic patients. HASMC also induce mast cell …