Presentation, diagnosis and clinical course of the spectrum of progressive-fibrosing interstitial lung diseases

V Cottin, NA Hirani, DL Hotchkin… - European …, 2018 - Eur Respiratory Soc
Although these conditions are rare, a proportion of patients with interstitial lung diseases (ILDs)
may develop a progressive-fibrosing phenotype. Progressive fibrosis is associated with …

Ly6Chi Monocytes Direct Alternatively Activated Profibrotic Macrophage Regulation of Lung Fibrosis

…, C Haslett, SE Howie, AJ Simpson, N Hirani… - American journal of …, 2011 - atsjournals.org
Nikhil HiraniNikhil Hirani … Gibbons MA, MacKinnon AC, Ramachandran P, Duffin R,
Dhaliwal K, Haslett C, Howie SEM, Simpson AJ, Hirani N, Gauldie J, et al.. Ly6C hi circulating …

IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis

…, RJ Fahy, TB Crotty, N Hirani… - Proceedings of the …, 2014 - National Acad Sciences
Disease conditions associated with pulmonary fibrosis are progressive and have a poor
long-term prognosis with irreversible changes in airway architecture leading to marked …

Elevated levels of interleukin-8 in donor lungs is associated with early graft failure after lung transplantation

AJ FISHER, SC DONNELLY, N HIRANI… - American journal of …, 2001 - atsjournals.org
Increased levels of the neutrophil chemokine interleukin (IL)-8 in the lungs of severe trauma
patients can predict subsequent development of acute respiratory distress syndrome. …

[HTML][HTML] Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis

N Hirani, AC MacKinnon, L Nicol, P Ford… - European …, 2021 - Eur Respiratory Soc
Galectin (Gal)-3 is a profibrotic β-galactoside-binding lectin that plays a key role in the
pathogenesis of idiopathic pulmonary fibrosis (IPF) and IPF exacerbations. TD139 is a novel and …

Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.

AG Rossi, C Haslett, N Hirani… - The Journal of …, 1998 - Am Soc Clin Investig
Macrophage migration inhibitory factor (MIF) is a potent proinflammatory mediator that has
been shown to potentiate lethal endotoxemia and to play a potentially important regulatory …

[HTML][HTML] The regulation of interleukin-8 by hypoxia in human macrophages—a potential role in the pathogenesis of the acute respiratory distress syndrome (ARDS)

N Hirani, F Antonicelli, RM Strieter, MS Wiesener… - Molecular …, 2001 - Springer
Background The acute respiratory distress syndrome (ARDS) represents a form of severe
acute inflammatory lung disease. We have previously demonstrated significantly raised …

[HTML][HTML] Predicting outcomes in rheumatoid arthritis related interstitial lung disease

J Jacob, N Hirani, CHM Van Moorsel… - European …, 2019 - Eur Respiratory Soc
The aim of this study was to compare radiology-based prediction models in rheumatoid
arthritis-related interstitial lung disease (RAILD) to identify patients with a progressive fibrosis …

[HTML][HTML] Hypoxia and hypoxia inducible factor-1α are required for normal endometrial repair during menstruation

JA Maybin, AA Murray, PTK Saunders, N Hirani… - Nature …, 2018 - nature.com
Heavy menstrual bleeding (HMB) is common and debilitating, and often requires surgery due
to hormonal side effects from medical therapies. Here we show that transient, physiological …

[HTML][HTML] Neutrophils induce macrophage anti-inflammatory reprogramming by suppressing NF-κB activation

…, J Stephen, AG Rossi, I Dransfield, N Hirani - Cell Death & …, 2018 - nature.com
Apoptotic cells modulate the function of macrophages to control and resolve inflammation.
Here, we show that neutrophils induce a rapid and sustained suppression of NF-κB signalling …