Non-typeable Haemophilus influenzae airways infection: the next treatable trait in asthma?

MA Brown, M Jabeen, G Bharj… - European Respiratory …, 2022 - Eur Respiratory Soc
Asthma is a complex, heterogeneous condition that affects over 350 million people globally.
It is characterised by bronchial hyperreactivity and airways inflammation. A subset display …

Perceptions of HIV pre-exposure prophylaxis among young, black men who have sex with men

L Elopre, C McDavid, A Brown, S Shurbaji… - AIDS patient care and …, 2018 - liebertpub.com
We conducted in-depth interviews guided by the Andersen–Newman Health Service Utilization
Framework to understand perceptions of pre-exposure prophylaxis (PrEP) with 25 young…

Guiding epithelial cell phenotypes with engineered integrin-specific recombinant fibronectin fragments

AC Brown, JA Rowe, TH Barker - Tissue Engineering Part A, 2011 - liebertpub.com
The extracellular matrix (ECM) provides important cues for directing cell phenotype. Cells
interact with underlying ECM through cell-surface receptors known as integrins, which bind to …

In‐field evaluation of Xpert® HCV viral load Fingerstick assay in people who inject drugs in Tanzania

…, SD Taylor‐Robinson, MR Thursz, AS Brown… - Liver …, 2020 - Wiley Online Library
Background Although novel hepatitis C virus (HCV) RNA point‐of‐care technology has the
potential to enhance the diagnosis in resource‐limited settings, very little real‐world …

[PDF][PDF] The UK‐PBC risk scores: derivation and validation of a scoring system for long‐term prediction of end‐stage liver disease in primary biliary cholangitis

…, A Ala, A Broad, A Saeed, G Wood, J Brown… - …, 2016 - Wiley Online Library
The biochemical response to ursodeoxycholic acid (UDCA)—so‐called “treatment response”—strongly
predicts long‐term outcome in primary biliary cholangitis (PBC). Several long‐…

Decline in hepatitis C virus (HCV) incidence in men who have sex with men living with human immunodeficiency virus: progress to HCV microelimination in the United …

…, H Sharp, S Ullah, Y Gilleece, A Brown… - Clinical Infectious …, 2021 - academic.oup.com
Modeling of the London hepatitis C virus (HCV) epidemic in men who have sex with men (MSM)
and are living with human immunodeficiency virus (HIV) suggested that early access to …

Efficacy and safety of ledipasvir/sofosbuvir with and without ribavirin in patients with chronic HCV genotype 1 infection receiving opioid substitution therapy: analysis of …

J Grebely, S Mauss, A Brown… - Clinical Infectious …, 2016 - academic.oup.com
Background Interferon-based hepatitis C virus (HCV) therapy is safe and effective among
people receiving opioid substitution therapy (OST), but treatment uptake remains low. Our aim …

Cost‐effectiveness of strategies to improve HCV screening, linkage‐to‐care and treatment in remand prison settings in England

…, MR Thursz, M Lemoine, AS Brown… - Liver …, 2020 - Wiley Online Library
Background A simplified cascade‐of‐care may improve screening and treatment uptake
among incarcerated individuals. We assessed the cost‐effectiveness of traditional and …

Platelet-like particles dynamically stiffen fibrin matrices and improve wound healing outcomes

…, M Erb, L Gaffney, DO Freytes, AC Brown - Biomaterials …, 2019 - pubs.rsc.org
Native platelets perform several critical functions within the context of wound healing, including
participating in initial hemostasis and interacting with fibrin at the wound site to induce …

[HTML][HTML] The senescence-associated secretome as an indicator of age and medical risk

…, EJ Atkinson, YI Zhu, S Jachim, DL Mazula, AK Brown… - JCI insight, 2020 - ncbi.nlm.nih.gov
Produced by senescent cells, the senescence-associated secretory phenotype (SASP) is a
potential driver of age-related dysfunction. We tested whether circulating concentrations of …