Introduction Nosocomial pneumonia develops after ≥48 h of hospitalisation and is classified
as ventilator-associated pneumonia (VAP) and hospital-acquired pneumonia (HAP); the …

Background Age has been traditionally considered a risk factor for mortality in elderly patients
admitted to intensive care units. The aim of this prospective, observational, multicenter …

Background Recent reports have suggested the efficacy of a double carbapenem (DC)
combination, including ertapenem, for the treatment of carbapenem-resistant Klebsiella …

Background In critically ill patients, the use of high tigecycline dosages (HD TGC) (200 mg/day)
has been recently increasing but few pharmacokinetic/pharmacodynamic (PK/PD) data …

When a patient is critically ill, mechanical ventilation is often provided and is the most common
artificial assistance used in intensive care units (ICUs). Ventilator-associated pneumonia (…

Clostridioides difficile (formerly Clostridium difficile) infection (CDI) represents a worrisome
condition, often underestimated, with severe clinical presentations, frequently requiring …

Purpose Clinical application of an antibiotic’s pharmacokinetic/pharmacodynamic (PK/PD)
properties may improve the outcome of severe infections. No data are available on the use of …

Purpose To assess risk factors for 28-day mortality and cost implications in intensive care
unit (ICU) patients with complicated intra-abdominal infections (cIAIs). Methods Single-center …

Background To explore the association between endotoxin activity (EA) and septic cardiomyopathy
(SCM), the relationship between endotoxin removal by Polymyxin‐B hemoperfusion (…

Background To determine the safety and clinical efficacy of an innovative integrated airway
system (AnapnoGuard ™ 100 system) that continuously monitors and controls the cuff …