The rapid expansion of the elderly population has led to the recent epidemic of age-related
diseases, including increased incidence and mortality of chronic lung diseases, such as …

The cell type specific sequences of transcriptional programs during lung regeneration have
remained elusive. Using time-series single cell RNA-seq of the bleomycin lung injury model, …

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with poor prognosis and
limited therapeutic options. The incidence of IPF increases with age, and ageing-related …

Background Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Repetitive
injury and reprogramming of the lung epithelium are thought to be critical drivers of disease …

Idiopathic pulmonary fibrosis (IPF) is a devastating chronic interstitial lung disease (ILD)
characterized by lung tissue scarring and high morbidity. Lung epithelial injury, myofibroblast …

Rationale: Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease characterized by lung
epithelial cell injury, increased (myo)fibroblast activation, and extracellular matrix deposition. …

Rationale: Chronic obstructive pulmonary disease (COPD), in particular emphysema, is
characterized by loss of parenchymal alveolar tissue and impaired tissue repair. Wingless and …

Lymphotoxin β-receptor (LTβR) signalling promotes lymphoid neogenesis and the
development of tertiary lymphoid structures 1 , 2 , which are associated with severe chronic …

The acquisition of mesenchymal traits is considered a hallmark of breast cancer progression.
However, the functional relevance of epithelial-to-mesenchymal transition (EMT) remains …

Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and idiopathic
pulmonary fibrosis (IPF), represent a significant and increasing health burden. Current …