Inflammatory conditions are associated with the extracellular release of nucleotides,
particularly ATP. In the extracellular compartment, ATP predominantly functions as a signalling …

Human IL-1 family proteins are key mediators of the host response to infections, injury, and
immunologic challenges. The mechanism by which IL-1 activates proinflammatory responses …

The success of allogeneic hematopoietic cell transplantation is limited by acute graft-versus-host
disease (GvHD), a severe complication accompanied by high mortality rates. Yet, the …

Extracellular ATP serves as a danger signal to alert the immune system of tissue damage by
acting on P2X or P2Y receptors. Here we show that allergen challenge causes acute …

Danger signals released upon cell damage can cause excessive immune-mediated tissue
destruction such as that found in acute graft-versus-host disease (GVHD), allograft rejection …

The majority of peripheral serotonin is stored in platelets, which secrete it on activation.
Serotonin releases Weibel-Palade bodies (WPBs) and we asked whether absence of platelet …

Extracellular ATP is a mediator of intercellular communication and a danger signal. Release
of this and other nucleotides modulates microglia responses via P2Y and P2X receptors, …

Although asthma is very common, affecting 5–10% of the population, the diagnosis of
asthma in adults remains a challenge in the real world, which results in both over- and under-…

Airway DCs play a crucial role in the pathogenesis of allergic asthma, and interfering with
their function could constitute a novel form of therapy. The sphingosine 1–phosphate receptor …

The neurotransmitter 5-hydroxytryptamine (5-HT), commonly known as serotonin, is stored
at peripheral sites in mast cells and released from this peripheral source upon IgE cross-…