User profiles for Mangalakumari Jeyanathan
 | Mangalakumari JeyanathanSenior Research Scientist, McMaster University Verified email at mcmaster.ca Cited by 4695 |
[HTML][HTML] Immunological considerations for COVID-19 vaccine strategies
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to humanity in a …
syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to humanity in a …
[HTML][HTML] COVID‐19: Current knowledge in clinical features, immunological responses, and vaccine development
R Singh, A Kang, X Luo, M Jeyanathan… - The FASEB …, 2021 - ncbi.nlm.nih.gov
The COVID‐19 pandemic has unfolded to be the most challenging global health crisis in a
century. In 11 months since its first emergence, according to WHO, the causative infectious …
century. In 11 months since its first emergence, according to WHO, the causative infectious …
[PDF][PDF] Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …
COVID-19 vaccines administered intramuscularly and designed to only target the spike …
Adenoviral-vectored next-generation respiratory mucosal vaccines against COVID-19
The world is in need of next-generation COVID-19 vaccines. Although first-generation injectable
COVID-19 vaccines continue to be critical tools in controlling the current global health …
COVID-19 vaccines continue to be critical tools in controlling the current global health …
[PDF][PDF] Induction of autonomous memory alveolar macrophages requires T cell help and is critical to trained immunity
Y Yao, M Jeyanathan, S Haddadi, NG Barra… - Cell, 2018 - cell.com
Innate immune memory is an emerging area of research. However, innate immune memory
at major mucosal sites remains poorly understood. Here, we show that respiratory viral …
at major mucosal sites remains poorly understood. Here, we show that respiratory viral …
Influenza infection leads to increased susceptibility to subsequent bacterial superinfection by impairing NK cell responses in the lung
…, CR Shaler, S McCormick, M Jeyanathan… - The Journal of …, 2010 - journals.aai.org
Influenza viral infection is well-known to predispose to subsequent bacterial superinfection
in the lung but the mechanisms have remained poorly defined. We have established a …
in the lung but the mechanisms have remained poorly defined. We have established a …
[HTML][HTML] Parenteral BCG vaccine induces lung-resident memory macrophages and trained immunity via the gut–lung axis
Aside from centrally induced trained immunity in the bone marrow (BM) and peripheral
blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate …
blood by parenteral vaccination or infection, evidence indicates that mucosal-resident innate …
A human type 5 adenovirus–based tuberculosis vaccine induces robust T cell responses in humans despite preexisting anti-adenovirus immunity
There is an urgent need to develop new tuberculosis (TB) vaccines to safely and effectively
boost Bacille Calmette-Guérin (BCG)–triggered T cell immunity in humans. AdHu5Ag85A is a …
boost Bacille Calmette-Guérin (BCG)–triggered T cell immunity in humans. AdHu5Ag85A is a …
[HTML][HTML] Aerosol delivery, but not intramuscular injection, of adenovirus-vectored tuberculosis vaccine induces respiratory-mucosal immunity in humans
M Jeyanathan, DK Fritz, S Afkhami, E Aguirre… - JCI insight, 2022 - ncbi.nlm.nih.gov
Background Adenovirus-vectored (Ad-vectored) vaccines are typically administered via im
injection to humans and are incapable of inducing respiratory mucosal immunity. However, …
injection to humans and are incapable of inducing respiratory mucosal immunity. However, …
Extrapulmonary Locations of Mycobacterium tuberculosis DNA During Latent Infection
…, M Saqui-Salces, M Jeyanathan… - The Journal of …, 2012 - academic.oup.com
Background. One-third of the world's population has latent infection with Mycobacterium
tuberculosis, and 10%–15% of cases of reactivation occur at extrapulmonary sites without active …
tuberculosis, and 10%–15% of cases of reactivation occur at extrapulmonary sites without active …