Simple Summary Lung adenocarcinoma (LUAD) is the major subtype of lung cancer and
represents the deadliest human cancer, affecting current-, ex-, and even non-smokers. LUAD is …

Mast cells (MCs) have been identified in various tumors; however, the role of these cells in
tumorigenesis remains controversial. Here, we quantified MCs in human and murine …

Malignant pleural effusion (MPE) is the lethal consequence of various human cancers
metastatic to the pleural cavity. However, the mechanisms responsible for the development of …

10.7554/eLife.45571.001 Lung cancer and chronic lung diseases impose major disease
burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The …

Evasion of programmed cell death represents a critical form of oncogene addiction in cancer
cells. Understanding the molecular mechanisms underpinning cancer cell survival despite …

Transcription factors (TFs) consisting of zinc fingers combined with BTB (for broad-complex,
tram-track, and bric-a-brac) domain (ZBTB) are a highly conserved protein family that …

Although oncogenic activation of NFκB has been identified in various tumors, the NFκB–activating
kinases (inhibitor of NFκB kinases, IKK) responsible for this are elusive. In this study, …

The cellular origin of lung adenocarcinoma remains a focus of intense research efforts. The
marked cellular heterogeneity and plasticity of the lungs, as well as the vast variety of …

The lungs are frequently affected by cancer metastasis. Although NRAS mutations have
been associated with metastatic potential, their exact role in lung homing is incompletely …

Malignant pleural effusion (MPE) is a frequent metastatic manifestation of human cancers.
While we previously identified KRAS mutations as molecular culprits of MPE formation, the …