Protein identification and analysis software performs a central role in the investigation of
proteins from two-dimensional (2-D) gels and mass spectrometry. For protein identification, the …

… Wilkins has received speaker and/or consulting fees from Bayer, GlaxoSmithKline, Pfizer,
and Novartis; and has received research funding from the British Heart Foundation, Wellcome …

The advent of large genolne sequencing projects has changed the scale of biology. Over a
relatively short period of tinle, we have witnessed the elucidation of the conlplete nucleotide …

A protein map of the smallest known self‐replicating organism, Mycoplasma genitalium (Class:
Mollicutes), revealed a high proportion of acidic proteins. Amino acid composition was …

Separation and identification of proteins by two-dimensional (2-D) electrophoresis can be
used for protein-based gene expression analysis. In this report single protein spots, from …

Background Riociguat, a member of a new class of compounds (soluble guanylate cyclase
stimulators), has been shown in previous clinical studies to be beneficial in the treatment of …

Our understanding of, and approach to, pulmonary arterial hypertension has undergone a
paradigm shift in the past decade. Once a condition thought to be dominated by increased …

Background This study investigated the effect of the phosphodiesterase 5 inhibitor sildenafil
on the pulmonary vascular response to hypoxia in humans and mice. Methods and Results …

Both the generation and the analysis of proteomics data are now widespread, and high-throughput
approaches are commonplace. Protocols continue to increase in complexity as …

… Dr Wilkins is supported by grants from the British Heart Foundation and Medical Research
Council. All authors had full access to the manuscript and approved the final version. …