Abstract Changes in food composition and availability have contributed to the dramatic
increase in obesity over the past 30–40 years in developed and, increasingly, in developing …

Background The randomised phase 2 CABOSUN trial comparing cabozantinib with sunitinib
as initial therapy for advanced renal cell carcinoma (RCC) of intermediate or poor risk met …

Stress activates the hypothalamic–pituitary–adrenal (HPA) axis, which then modulates the
degree of adaptation and response to a later stressor. It is known that early-life stress can …

Toward development of a precision medicine framework for metastatic, castration-resistant
prostate cancer (mCRPC), we established a multi-institutional clinical sequencing …

Background Metastatic castration-resistant prostate cancer remains fatal despite recent
advances. Prostate-specific membrane antigen (PSMA) is highly expressed in metastatic …

The global prevalence of obesity is increasing across most ages in both sexes. This is
contributing to the early emergence of type 2 diabetes and its related epidemic 1 , 2 . Having …

The lack of in vitro prostate cancer models that recapitulate the diversity of human prostate
cancer has hampered progress in understanding disease pathogenesis and therapy response…

Background MDV3100 is an androgen-receptor antagonist that blocks androgens from binding
to the androgen receptor and prevents nuclear translocation and co-activator recruitment …

Purpose Evolving treatments, disease phenotypes, and biology, together with a changing
drug development environment, have created the need to revise castration-resistant prostate …

Study of 800 outpatient visits to Childrens Hospital of Los Angeles to explore the effect of the
verbal interaction between doctor and patient on patient satisfaction and follow-through on …