[HTML][HTML] Adherence to inhaled therapies, health outcomes and costs in patients with asthma and COPD

MJ Mäkelä, V Backer, M Hedegaard, K Larsson - Respiratory medicine, 2013 - Elsevier
Suboptimal adherence to pharmacological treatment of asthma and chronic obstructive
pulmonary disease (COPD) has adverse effects on disease control and treatment costs. The …

Monitoring asthma in children

…, G Hedlin, N Kulkarni, C Lex, MJ Mäkelä… - European …, 2015 - Eur Respiratory Soc
The goal of asthma treatment is to obtain clinical control and reduce future risks to the
patient. To reach this goal in children with asthma, ongoing monitoring is essential. While all …

EAACI position statement on asthma exacerbations and severe asthma

…, J Lötvall, P Demoly, CA Akdis, D Ryan, MJ Mäkelä… - Allergy, 2013 - Wiley Online Library
Asthma exacerbations and severe asthma are linked with high morbidity, significant mortality
and high treatment costs. Recurrent asthma exacerbations cause a decline in lung function …

Environmental biodiversity, human microbiota, and allergy are interrelated

…, P Auvinen, L Paulin, MJ Mäkelä… - Proceedings of the …, 2012 - National Acad Sciences
Rapidly declining biodiversity may be a contributing factor to another global megatrend—the
rapidly increasing prevalence of allergies and other chronic inflammatory diseases among …

Viruses and bacteria in the etiology of the common cold

MJ Mäkelä, T Puhakka, O Ruuskanen… - Journal of clinical …, 1998 - Am Soc Microbiol
Two hundred young adults with common colds were studied during a 10-month period. Virus
culture, antigen detection, PCR, and serology with paired samples were used to identify the …

Airway remodeling and inflammation in symptomatic infants with reversible airflow obstruction

…, A Bush, T Haahtela, MJ Mäkelä… - American journal of …, 2005 - atsjournals.org
Rationale: We hypothesized that the epithelial reticular basement membrane (RBM) thickening
and eosinophilic inflammation characteristic of asthma would be present in symptomatic …

Clinical course and prognosis of cow's milk allergy are dependent on milk-specific IgE status

KM Saarinen, AS Pelkonen, MJ Mäkelä… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: Large, prospective population-based studies on clinical course, development
of tolerance, and risk for other atopy in children with cow's milk allergy (CMA) are lacking. …

Impact of COVID-19 on pediatric asthma: practice adjustments and disease burden

…, S Lau, P Le Souef, RF Lemanske, MJ Mäkelä… - The Journal of Allergy …, 2020 - Elsevier
Background It is unclear whether asthma may affect susceptibility or severity of coronavirus
disease 2019 (COVID-19) in children and how pediatric asthma services worldwide have …

IL-10 is necessary for the expression of airway hyperresponsiveness but not pulmonary inflammation after allergic sensitization

MJ Mäkelä, A Kanehiro, L Borish… - Proceedings of the …, 2000 - National Acad Sciences
Cytokines play an important role in modulating inflammatory responses and, as a result,
airway tone. IL-10 is a regulatory cytokine that has been suggested for treatment of asthma …

Hunt for the origin of allergy–comparing the Finnish and Russian Karelia

…, TU Kosunen, O Markelova, MJ Mäkelä… - Clinical & …, 2015 - Wiley Online Library
The Finnish and Russian Karelia are adjacent areas in northern Europe, socio‐economically
distinct but geoclimatically similar. The Karelia Allergy Study was commenced in 1998 to …