… Author links open overlay panel Laura C. Price MBChB a b c d , S. John Wort MBChB, PhD
… .28, 30 A recent study has identified an increase in c-kit-positive cells (including mast cells) in …

At the end of last year, a novel coronavirus, severe acute respiratory syndrome coronavirus
2 (SARS-CoV-2), resulted in an acute respiratory illness epidemic in Wuhan, China [1, 2]. …

Introduction Pulmonary vascular dysfunction, pulmonary hypertension (PH), and resulting
right ventricular (RV) failure occur in many critical illnesses and may be associated with a …

Pulmonary arterial hypertension (PAH) is a chronic and progressive disease leading to right
heart failure and ultimately death if untreated. The first classification of PH was proposed in …

Acute right ventricular failure in the setting of pulmonary arterial hypertension (PAH) often
requires hospitalisation in intensive care units (ICU) to manage the subsequent low cardiac …

… d e , Christophe Guignabert a b c , Sven Günther a b c , Barbara Girerd a b c , Xavier Jaïs
a b c , Vincent Algalarrondo a f , Laura C. Price g , Laurent Savale a b c , Olivier Sitbon a b c , …

Background: Acute chronic obstructive pulmonary disease (COPD) exacerbations use many
hospital bed days and have a high rate of mortality. Previous audits have shown wide …

Rationale: C-kit + cells, including bone marrow (BM)–derived progenitors and mast cells,
may participate in vascular remodelling. Because recent studies suggest that c-kit may be a …

Aims Comprehensive echocardiography assessment of right ventricular (RV) impairment has
not been reported in critically ill patients with COVID-19. We detail the specific phenotype …

Acute lung injury (ALI) and acute respiratory distress syndrome are characterized by protein
rich alveolar edema, reduced lung compliance, and acute severe hypoxemia. A degree of …