The emergence of SARS-CoV-2 led to pandemic spread of coronavirus disease 2019 (COVID-19),
manifesting with respiratory symptoms and multi-organ dysfunction. Detailed …

The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has precipitated an unprecedented and yet-…

In late 2019, an outbreak of a severe respiratory disease caused by an emerging coronavirus,
SARS-CoV-2, resulted in high morbidity and mortality in infected humans. Complete …

The SARS‐CoV‐2 pandemic has caused a yet unresolved global crisis. Effective medical
intervention by vaccination or therapy seems to be the only possibility to control the pandemic. …

Derailed cytokine and immune cell networks account for the organ damage and the clinical
severity of COVID-19 (refs. ). Here we show that SARS-CoV-2, like other viruses, evokes …

Viruses manipulate cellular metabolism and macromolecule recycling processes like
autophagy. Dysregulated metabolism might lead to excessive inflammatory and autoimmune …

In COVID-19, immune responses are key in determining disease severity. However, cellular
mechanisms at the onset of inflammatory lung injury in SARS-CoV-2 infection, particularly …

Codon pair deoptimization is an efficient virus attenuation strategy, but the mechanism that
leads to attenuation is unknown. The strategy involves synthetic recoding of viral genomes …

Vaccines play a critical role in combating the COVID-19 pandemic. Future control of the
pandemic requires improved vaccines with high efficacy against newly emerging SARS-CoV-2 …

Search of new strategies for the inhibition of respiratory viruses is one of the urgent health
challenges worldwide, as most of the current therapeutic agents and treatments are inefficient. …