User profiles for Ian P. Hall

IP Hall

University of Nottingham
Verified email at nottingham.ac.uk
Cited by 24759

Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction

…, K Deichmann, PJ Thompson, M Wjst, IP Hall… - Nature …, 2009 - nature.com
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of inflammatory responses and thus have important roles in the pathogenesis of …

Genome-wide association study identifies five loci associated with lung function

…, C Hayward, DM Evans, P Elliott, DP Strachan, IP Hall… - Nature …, 2010 - nature.com
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …

[HTML][HTML] Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in …

…, J Marchini, DP Strachan, MD Tobin, IP Hall - The Lancet …, 2015 - thelancet.com
Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). …

Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells.

SA Green, J Turki, P Bejarano, IP Hall… - American journal of …, 1995 - atsjournals.org
The phenotypic relevance of allelic variation in the structure of the beta 2-adrenergic receptor
(beta 2AR) expressed in lung cells is unknown. In particular, altered responsiveness of the …

IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction

…, CM Kane, DR Neill, RJ Flynn, I Sayers, IP Hall… - Journal of allergy and …, 2013 - Elsevier
Background IL-25 and IL-33 belong to distinct cytokine families, but experimental mouse
studies suggest their immunologic functions in type 2 immunity are almost entirely overlapping. …

New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries

…, DA Meyers, MH Cho, DP Strachan, IP Hall… - Nature …, 2019 - nature.com
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …

Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis

…, Y Bossé, N Shrine, MS Artigas, LV Wain, IP Hall… - Nature …, 2017 - nature.com
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide 1 .
We performed a genetic association study in 15,256 cases and 47,936 controls, with …

Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets

…, M Obeidat, AP Henry, MA Portelli, RJ Hall… - Nature …, 2017 - nature.com
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association discovery …

[HTML][HTML] Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study

…, W Timens, N Shrine, I Sayers, IP Hall… - The Lancet respiratory …, 2017 - thelancet.com
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with
high mortality, uncertain cause, and few treatment options. Studies have identified a significant …

Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations

…, TE Fingerlin, SA Gharib, A Gulsvik, IP Hall… - Nature …, 2019 - nature.com
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …