User profiles for Ian P. Hall
IP HallUniversity of Nottingham Verified email at nottingham.ac.uk Cited by 24759 |
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of inflammatory responses and thus have important roles in the pathogenesis of …
of inflammatory responses and thus have important roles in the pathogenesis of …
Genome-wide association study identifies five loci associated with lung function
Pulmonary function measures are heritable traits that predict morbidity and mortality and
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
define chronic obstructive pulmonary disease (COPD). We tested genome-wide association …
[HTML][HTML] Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in …
Background Understanding the genetic basis of airflow obstruction and smoking behaviour
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). …
is key to determining the pathophysiology of chronic obstructive pulmonary disease (COPD). …
Influence of beta 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells.
SA Green, J Turki, P Bejarano, IP Hall… - American journal of …, 1995 - atsjournals.org
The phenotypic relevance of allelic variation in the structure of the beta 2-adrenergic receptor
(beta 2AR) expressed in lung cells is unknown. In particular, altered responsiveness of the …
(beta 2AR) expressed in lung cells is unknown. In particular, altered responsiveness of the …
IL-33 is more potent than IL-25 in provoking IL-13–producing nuocytes (type 2 innate lymphoid cells) and airway contraction
Background IL-25 and IL-33 belong to distinct cytokine families, but experimental mouse
studies suggest their immunologic functions in type 2 immunity are almost entirely overlapping. …
studies suggest their immunologic functions in type 2 immunity are almost entirely overlapping. …
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Reduced lung function predicts mortality and is key to the diagnosis of chronic obstructive
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
pulmonary disease (COPD). In a genome-wide association study in 400,102 individuals of …
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
Chronic obstructive pulmonary disease (COPD) is a leading cause of mortality worldwide 1 .
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
We performed a genetic association study in 15,256 cases and 47,936 controls, with …
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets
…, M Obeidat, AP Henry, MA Portelli, RJ Hall… - Nature …, 2017 - nature.com
Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function
and is the third leading cause of death globally. Through genome-wide association discovery …
and is the third leading cause of death globally. Through genome-wide association discovery …
[HTML][HTML] Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Background Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease with
high mortality, uncertain cause, and few treatment options. Studies have identified a significant …
high mortality, uncertain cause, and few treatment options. Studies have identified a significant …
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
Chronic obstructive pulmonary disease (COPD) is the leading cause of respiratory mortality
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …
worldwide. Genetic risk loci provide new insights into disease pathogenesis. We performed …