User profiles for Harris Perlman
 | Harris PerlmanNorthwestern University Verified email at northwestern.edu Cited by 21205 |
[PDF][PDF] Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis
Mononuclear phagocytes, including monocytes, macrophages, and dendritic cells, contribute
to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence …
to tissue integrity as well as to innate and adaptive immune defense. Emerging evidence …
[PDF][PDF] Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
It is widely appreciated that T cells increase glycolytic flux during activation, but the role of
mitochondrial flux is unclear. Here, we have shown that mitochondrial metabolism in the …
mitochondrial flux is unclear. Here, we have shown that mitochondrial metabolism in the …
Single-cell transcriptomic analysis of human lung provides insights into the pathobiology of pulmonary fibrosis
Rationale: The contributions of diverse cell populations in the human lung to pulmonary
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes …
fibrosis pathogenesis are poorly understood. Single-cell RNA sequencing can reveal changes …
Flow cytometric analysis of macrophages and dendritic cell subsets in the mouse lung
The lung hosts multiple populations of macrophages and dendritic cells, which play a crucial
role in lung pathology. The accurate identification and enumeration of these subsets are …
role in lung pathology. The accurate identification and enumeration of these subsets are …
Monocyte-derived alveolar macrophages drive lung fibrosis and persist in the lung over the life span
Little is known about the relative importance of monocyte and tissue-resident macrophages
in the development of lung fibrosis. We show that specific genetic deletion of monocyte-…
in the development of lung fibrosis. We show that specific genetic deletion of monocyte-…
Defining inflammatory cell states in rheumatoid arthritis joint synovial tissues by integrating single-cell transcriptomics and mass cytometry
To define the cell populations that drive joint inflammation in rheumatoid arthritis (RA), we
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…
applied single-cell RNA sequencing (scRNA-seq), mass cytometry, bulk RNA sequencing (…
Overexpression of bcl-2 Protects Prostate Cancer Cells from Apoptosis in Vitro and Confers Resistance to Androgen Depletion in Vivo
Normal (nonneoplastic) human prostatic secretory epithelial cells do not express the bcl-2
protein. However, a recent immunohistochemical survey of neoplastic human prostate tissues …
protein. However, a recent immunohistochemical survey of neoplastic human prostate tissues …
Exosomes From Human CD34+ Stem Cells Mediate Their Proangiogenic Paracrine Activity
Rationale: Transplantation of human CD34 + stem cells to ischemic tissues has been associated
with reduced angina, improved exercise time, and reduced amputation rates in phase 2 …
with reduced angina, improved exercise time, and reduced amputation rates in phase 2 …
Distinct fibroblast subsets drive inflammation and damage in arthritis
The identification of lymphocyte subsets with non-overlapping effector functions has been
pivotal to the development of targeted therapies in immune-mediated inflammatory diseases (…
pivotal to the development of targeted therapies in immune-mediated inflammatory diseases (…
A novel Ly6C/Ly6G‐based strategy to analyze the mouse splenic myeloid compartment
S Rose, A Misharin, H Perlman - Cytometry Part A, 2012 - Wiley Online Library
Currently, there is no standardized panel for immunophenotyping myeloid cells in mouse
spleen using flow cytometry. Markers such as CD11b, CD11c, F4/80, Gr‐1, Ly6C, and Ly6G …
spleen using flow cytometry. Markers such as CD11b, CD11c, F4/80, Gr‐1, Ly6C, and Ly6G …