Cyclophosphamide for connective tissue disease–associated interstitial lung disease

H Barnes, AE Holland, GP Westall… - Cochrane Database …, 2018 - cochranelibrary.com
Background Approximately one‐third of individuals with interstitial lung disease (ILD) have
associated connective tissue disease (CTD). The connective tissue disorders most commonly …

Oxygen therapy for interstitial lung disease: a systematic review

…, NS Cox, N Goh, I Glaspole, GP Westall… - European …, 2017 - Eur Respiratory Soc
This review aims to establish the impact of oxygen therapy on dyspnoea, health-related
quality of life (HRQoL), exercise capacity and mortality in interstitial lung disease (ILD). We …

[PDF][PDF] CD8+ T cells specific for an immunodominant SARS-CoV-2 nucleocapsid epitope display high naive precursor frequency and TCR promiscuity

…, KL Flanagan, S Sonda, J Kaur, LM Wakim, GP Westall… - Immunity, 2021 - cell.com
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),
it is important to examine unmanipulated severe acute respiratory syndrome …

Circulating TFH cells, serological memory, and tissue compartmentalization shape human influenza-specific B cell immunity

…, T Loudovaris, SI Mannering, GP Westall… - Science translational …, 2018 - science.org
Immunization with the inactivated influenza vaccine (IIV) remains the most effective strategy
to combat seasonal influenza infections. IIV activates B cells and T follicular helper (T FH ) …

[HTML][HTML] Human CD8+ T cell cross-reactivity across influenza A, B and C viruses

…, AC Cheng, M Richards, GP Westall… - Nature …, 2019 - nature.com
Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally and infect
humans, with IAV and IBV causing the most severe disease. CD8 + T cells confer cross-…

[HTML][HTML] MAIT cells protect against pulmonary Legionella longbeachae infection

…, AW Stent, DI Godfrey, J Rossjohn, GP Westall… - Nature …, 2018 - nature.com
Mucosal associated invariant T (MAIT) cells recognise conserved microbial metabolites from
riboflavin synthesis. Striking evolutionary conservation and pulmonary abundance implicate …

[HTML][HTML] Influenza-specific lung-resident memory T cells are proliferative and polyfunctional and maintain diverse TCR profiles

…, SI Mannering, PG Thomas, GP Westall… - The Journal of …, 2018 - Am Soc Clin Investig
The human lung harbors a large population of resident memory T cells (Trm cells). These cells
are perfectly positioned to mediate rapid protection against respiratory pathogens such as …

Lung transplantation in Australia, 1986–2018: more than 30 years in the making

MA Paraskeva, KC Levin, GP Westall… - Medical Journal of …, 2018 - Wiley Online Library
Lung transplantation in Australia is 32 years old in 2018. From its early infancy in 1986, it
continues to evolve and is internationally recognised as demonstrating world's best practices in …

A class of γδ T cell receptors recognize the underside of the antigen-presenting molecule MR1

…, HH Reid, L Liu, DP Fairlie, EM Giles, GP Westall… - Science, 2019 - science.org
T cell receptors (TCRs) recognize antigens presented by major histocompatibility complex (MHC)
and MHC class I–like molecules. We describe a diverse population of human γδ T …

[HTML][HTML] HLA matching at the eplet level protects against chronic lung allograft dysfunction

…, ST Wright, GI Snell, MA Paraskeva, GP Westall - American journal of …, 2016 - Elsevier
Donor selection in lung transplantation (LTx) is historically based upon clinical urgency,
ABO compatibility, and donor size. HLA matching is not routinely considered; however, the …