Cell therapy for lung disease

S Geiger, D Hirsch, FG Hermann - European respiratory review, 2017 - Eur Respiratory Soc
Besides cancer and cardiovascular diseases, lung disorders are a leading cause of morbidity
and death worldwide. For many disease conditions no effective and curative treatment …

Woodchuck hepatitis virus post-transcriptional regulatory element deleted from X protein and promoter sequences enhances retroviral vector titer and expression

A Schambach, J Bohne, C Baum, FG Hermann… - Gene therapy, 2006 - nature.com
Introduction of the post-transcriptional regulatory element (PRE) of woodchuck hepatitis
virus (WHV) into the 3′ untranslated region of retroviral and lentiviral gene transfer vectors …

[HTML][HTML] IL7-IL12 engineered mesenchymal stem cells (MSCs) improve a CAR T cell attack against colorectal cancer cells

AA Hombach, U Geumann, C Günther, FG Hermann… - Cells, 2020 - mdpi.com
Chimeric antigen receptor (CAR) redirected T cells are efficacious in the treatment of
leukemia/lymphoma, however, showed less capacities in eliminating solid tumors which is thought …

Local intracerebral immunomodulation using interleukin-expressing mesenchymal stem cells in glioblastoma

…, C Guenther, K Lamszus, FG Hermann… - Clinical Cancer …, 2020 - AACR
Purpose: Mesenchymal stem cells (MSCs) show an inherent brain tumor tropism that can be
exploited for targeted delivery of therapeutic genes to invasive glioma. We assessed …

[HTML][HTML] Preclinical analysis of human mesenchymal stem cells: tumor tropism and therapeutic efficiency of local HSV-TK suicide gene therapy in glioblastoma

…, C Guenther, M Westphal, K Lamszus, FG Hermann… - Oncotarget, 2019 - ncbi.nlm.nih.gov
Glioblastoma are highly invasive and associated with limited therapeutic options and a grim
prognosis. Using stem cells to extend current therapeutic strategies by targeted drug …

Efficient entry inhibition of human and nonhuman primate immunodeficiency virus by cell surface-expressed gp41-derived peptides

RC Zahn, FG Hermann, EY Kim, MD Rett, SM Wolinsky… - Gene therapy, 2008 - nature.com
… Given that the efficiency of virus entry inhibition is dependent on the level of maC46 cell
surface expression (FG Hermann et al., unpublished observations), we next sought to determine …

Mutations in gp120 contribute to the resistance of human immunodeficiency virus type 1 to membrane-anchored C-peptide maC46

FG Hermann, L Egerer, F Brauer, C Gerum… - Journal of …, 2009 - Am Soc Microbiol
Binding of the human immunodeficiency virus (HIV) envelope glycoprotein (Env) to the cellular
CD4 receptor and a chemokine coreceptor initiates a series of conformational changes in …

[HTML][HTML] Secreted antiviral entry inhibitory (SAVE) peptides for gene therapy of HIV infection

…, A Volk, J Kahle, J Kimpel, F Brauer, FG Hermann… - Molecular Therapy, 2011 - cell.com
Gene therapeutic strategies for human immunodeficiency virus type 1 (HIV-1) infection could
potentially overcome the limitations of standard antiretroviral drug therapy (ART). However, …

Towards hematopoietic stem cell-mediated protection against infection with human immunodeficiency virus

…, Z Li, K Kamino, J Bohne, A Alexandrov, FG Hermann… - Gene therapy, 2006 - nature.com
The failure of pharmacological approaches to cure infection with the human immunodeficiency
virus (HIV) has renewed the interest in gene-based therapies. Among the various …

Protein scaffold and expression level determine antiviral activity of membrane-anchored antiviral peptides

FG Hermann, H Martinius, M Egelhofer… - Human gene …, 2009 - liebertpub.com
… Of note, we have taken advantage of this correlation to select a maC46-resistant HIV variant
by passaging on cell lines with increasing levels of maC-peptide (FG Hermann, L. Egerer, F. …