The long-term solution to the asthma epidemic is thought to be prevention, and not treatment
of established disease. Atopic asthma arises from gene–environment interactions, which …

… A highly sensitive search strategy was developed and validated study design filters were
applied to search nine electronic bibliographic databases. The search strategy was developed …

Five biologicals have been approved for severe eosinophilic asthma, a well‐recognized
phenotype. Systematic reviews (SR) evaluated the efficacy and safety of benralizumab, …

To study the mechanisms and kinetics underlying the development of increased airway
responsiveness (AR) after allergic sensitization, animal models have been invaluable. Using …

This update and revision of the international guideline for urticaria was developed following
the methods recommended by Cochrane and the Grading of Recommendations Assessment…

Allergic rhinoconjunctivitis (AR) is an allergic disorder of the nose and eyes affecting about
a fifth of the general population. Symptoms of AR can be controlled with allergen avoidance …

Background Microbial intestinal colonization in early in life is regarded to play a major role
for the maturation of the immune system. Application of non‐pathogenic probiotic bacteria …

Mast cells are the main effector cells of immediate hypersensitivity and anaphylaxis. Their
role in the development of allergen-induced airway hyperresponsiveness (AHR) is …

The present guideline (S2k) on allergen-specific immunotherapy (AIT) was established by
the German, Austrian and Swiss professional associations for allergy in consensus with the …

… supplementation of a bacterial lysate of E coli and E faecalis. The allocated intervention did
… E. Hamelmann has received grants from DFG. The rest of the authors declare that they have …