[HTML][HTML] Hospital admission and emergency care attendance risk for SARS-CoV-2 delta (B. 1.617. 2) compared with alpha (B. 1.1. 7) variants of concern: a cohort …

…, N Cortes, J Lynch, S Kidd, D Fairley… - The Lancet Infectious …, 2022 - thelancet.com
Background The SARS-CoV-2 delta (B.1.617.2) variant was first detected in England in March,
2021. It has since rapidly become the predominant lineage, owing to high transmissibility. …

Emergence and global spread of epidemic healthcare-associated Clostridium difficile

…, MJ Martin, TR Connor, SR Harris, D Fairley… - Nature …, 2013 - nature.com
Epidemic C. difficile (027/BI/NAP1) has rapidly emerged in the past decade as the leading
cause of antibiotic-associated diarrhea worldwide. However, the key events in evolutionary …

[PDF][PDF] Evaluating the effects of SARS-CoV-2 spike mutation D614G on transmissibility and pathogenicity

…, E Wise, N Cortes, J Lynch, S Kidd, M Mori, DJ Fairley… - Cell, 2021 - cell.com
Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G
are suggestive of a selective advantage but may also be due to a random founder effect. We …

[PDF][PDF] Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B. 1.1. 7

…, C Moore, EM Harrison, S Goncalves, DJ Fairley… - Cell reports, 2021 - cell.com
We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70
in multiple independent lineages, often occurring after acquisition of receptor binding motif …

[HTML][HTML] Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B. 1.1. 7: an ecological study

…, M Mori, N Cortes, J Lynch, S Kidd, DJ Fairley… - The Lancet Public …, 2021 - thelancet.com
Background The SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in
England. We aimed to investigate whether increases in the proportion of infections with this …

CAMP factor homologues in Propionibacterium acnes: a new protein family differentially expressed by types I and II

…, S O'Hagan, GB Wisdom, D Fairley… - …, 2005 - microbiologyresearch.org
Analysis of the draft genome sequence of the opportunistic pathogen Propionibacterium acnes
type strain NCTC 737 (=ATCC 6919) revealed five genes with sequence identity to the co-…

[HTML][HTML] Respiratory viral infection: a potential “missing link” in the pathogenesis of COPD

…, H Guo-Parke, PV Coyle, D Fairley… - European …, 2019 - Eur Respiratory Soc
Chronic obstructive pulmonary disease (COPD) is currently the third most common cause of
global mortality. Acute exacerbations of COPD frequently necessitate hospital admission to …

Evolutionary remodelling of N‐terminal domain loops fine‐tunes SARS‐CoV‐2 spike

…, J McKenna, S Bridgett, D Simpson, D Fairley… - EMBO …, 2022 - embopress.org
The emergence of SARS‐CoV‐2 variants has exacerbated the COVID‐19 global health
crisis. Thus far, all variants carry mutations in the spike glycoprotein, which is a critical …

Adaptation of host transmission cycle during Clostridium difficile speciation

…, K Harcourt, MD Stares, G Dougan, DJ Fairley… - Nature …, 2019 - nature.com
Bacterial speciation is a fundamental evolutionary process characterized by diverging genotypic
and phenotypic properties. However, the selective forces that affect genetic adaptations …

The common vaginal commensal bacterium Ureaplasma parvum is associated with chorioamnionitis in extreme preterm labor

…, C Gannon, JP McKenna, DJ Fairley… - The Journal of …, 2016 - Taylor & Francis
Objective: To assess the association of vaginal commensal and low-grade pathogenic
bacteria including Ureaplasma parvum, Ureaplasma urealyticum, Mycoplasma hominis, …