Background More than 80% of donor lungs are potentially injured and therefore not considered
suitable for transplantation. With the use of normothermic ex vivo lung perfusion (EVLP), …

Stimulation of β 2 -adrenergic receptors on the cell surface by adrenaline or noradrenaline
leads to alterations in the metabolism, excitability, differentiation and growth of many cell types…

Acute lung injury (ALI) and its most severe form, the acute respiratory distress syndrome (ARDS)
are frequent complications in critically ill patients and are responsible for significant …

Background Few resources are available to support caregivers of patients who have survived
critical illness; consequently, the caregivers’ own health may suffer. We studied caregiver …

Rationale: Disability risk groups and 1-year outcome after greater than or equal to 7 days of
mechanical ventilation (MV) in medical/surgical intensive care unit (ICU) patients are …

Chronic lung diseases (CLDs) are regulated by complex interactions between many
different cell types residing in lung airway tissues. Specifically, interactions between airway …

CD44, a transmembrane adhesion molecule involved in binding and metabolism of
hyaluronan, has additional functions in inflammatory and immune responses, contributing to the …

Objective Acute respiratory distress syndrome (ARDS) represents an inflammatory process
that is initiated by diverse systemic and/or pulmonary insults, resulting in a clinical syndrome …

Rationale: Despite increasing evidence about the role of donor-specific human leukocyte
antigen (HLA) antibodies in transplant outcomes, the incidence and impact of de novo donor-…

Importance The mortality rate for individuals on the wait list for lung transplant is 15% to 25%,
and still only 20% of lungs from multiorgan donors are used for lung transplant. The lung …