The mechanisms through which estrogen prevents bone loss are uncertain. Elsewhere,
estrogen exerts beneficial actions by suppression of reactive oxygen species (ROS). ROS …

Background Emerging studies indicate that some coronavirus disease 2019 (COVID-19)
patients suffer from persistent symptoms, including breathlessness and chronic fatigue; however…

COVID-19 pathogenesis is associated with an exaggerated immune response. However,
the specific cellular mediators and inflammatory components driving diverse clinical disease …

We recently found that estrogen deficiency leads to a lowering of thiol antioxidant defenses
in rodent bone. Moreover, administration of agents that increase the concentration in bone of …

Little is known about the impact of viral infections on lung matrix despite its important contribution
to mechanical stability and structural support. The composition of matrix also indirectly …

Inflammatory cytokines and chemokines (CC) drive COVID-19 pathology. Yet, patients with
similar circulating CC levels present with different disease severity. Here, we determined 171 …

Background COVID-19 is associated with a dysregulated immune response but it is unclear
how immune dysfunction contributes to the chronic morbidity persisting in many COVID-19 …

Epidemiological studies suggest that a hookworm infection producing 50 eggs/gram of feces
may protect against asthma. We conducted a dose-ranging study to identify the dose of …

Secondary infections arise as a consequence of previous or concurrent conditions and
occur in the community or in the hospital setting. The events allowing secondary infections to …

No defects related to deficiency of the Wiskott-Aldrich Syndrome protein (WASp) have been
described in osteoclasts. Here we show that there are significant morphologic and functional …