Matrix abnormalities in pulmonary fibrosis

C Upagupta, C Shimbori, R Alsilmi… - European Respiratory …, 2018 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease, marked by excessive
scarring, which leads to increased tissue stiffness, loss in lung function and ultimately …

The importance of interventional timing in the bleomycin model of pulmonary fibrosis

P Kolb, C Upagupta, M Vierhout… - European …, 2020 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a complex disease of unknown aetiology, which makes
drug development challenging. Single administration of bleomycin directly to the lungs of …

What have we learned from basic science studies on idiopathic pulmonary fibrosis?

T Yanagihara, S Sato, C Upagupta… - European Respiratory …, 2019 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis is a fatal age-related lung disease characterised by progressive
and irreversible scarring of the lung. Although the details are not fully understood, there …

Mechanical stress-induced mast cell degranulation activates TGF-β1 signalling pathway in pulmonary fibrosis

C Shimbori, C Upagupta, PS Bellaye, EA Ayaub… - Thorax, 2019 - thorax.bmj.com
Background The role of mast cells accumulating in idiopathic pulmonary fibrosis (IPF) lungs
is unknown. Objectives We investigated the effect of fibrotic extracellular matrix (ECM) on …

Connective-tissue growth factor contributes to TGF-β1–induced lung fibrosis

…, Q Zhou, C Scallan, C Upagupta… - American journal of …, 2022 - atsjournals.org
Idiopathic pulmonary fibrosis is a fatal lung disease characterized by progressive and
excessive accumulation of myofibroblasts and in the lung. Connective-tissue growth factor (CTGF) …

Vascular–parenchymal cross-talk promotes lung fibrosis through BMPR2 signaling

…, S Sato, C Scallan, C Upagupta… - American Journal of …, 2023 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by
progressive lung scarring. IPF-related pulmonary vascular remodeling and pulmonary …

Lysyl oxidase–like 1 protein deficiency protects mice from adenoviral transforming growth factor-β1–induced pulmonary fibrosis

PS Bellaye, C Shimbori, C Upagupta… - American Journal of …, 2018 - atsjournals.org
Idiopathic pulmonary fibrosis (IPF) is a progressive disease characterized by excessive
deposition of extracellular matrix (ECM) in the lung parenchyma. The abnormal ECM deposition …

Macitentan reduces progression of TGF-β1-induced pulmonary fibrosis and pulmonary hypertension

…, S Sato, C Shimbori, C Upagupta… - European …, 2018 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive disease with an unknown cause. Two
drugs, nintedanib and pirfenidone, have been shown to slow, but not stop, disease progression…

Synergistic role of HSP90α and HSP90β to promote myofibroblast persistence in lung fibrosis

…, DA Carlson, P Hughes, C Upagupta… - European …, 2018 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a progressive disease of the lung parenchyma, causing
significant morbidity through worsening dyspnoea and overall functional decline. IPF is …

Endoplasmic reticulum stress inhibition limits the progression of chronic kidney disease in the Dahl salt-sensitive rat

…, E Brimble, J Chahal, C Upagupta… - American Journal …, 2017 - journals.physiology.org
Proteinuria is one of the primary risk factors for the progression of chronic kidney disease (CKD)
and has been implicated in the induction of endoplasmic reticulum (ER) stress. We …