User profiles for Carole Planes

Carole Planès

Inserm U 1272 "Hypoxie et Poumon" - Université Paris 13 ; Service Physiologie et …
Verified email at aphp.fr
Cited by 3039

Gene regulation in the adaptive process to hypoxia in lung epithelial cells

C Clerici, C Planès - American Journal of Physiology-Lung …, 2009 - journals.physiology.org
Lung alveolar epithelial cells are normally very well oxygenated but may be exposed to
hypoxia in many pathological conditions such as pulmonary edema, acute respiratory distress …

Pulmonary sarcoidosis

D Valeyre, JF Bernaudin, F Jeny… - Clinics in chest …, 2015 - chestmed.theclinics.com
Sarcoidosis is a systemic disease affecting the lung in almost all cases. 1–3 Whatever the
various revealing symptoms, the evidence of abnormal chest radiography is usually a key step …

Importance of ENaC-mediated sodium transport in alveolar fluid clearance using genetically-engineered mice

E Hummler, C Planès - Cellular Physiology and Biochemistry, 2009 - karger.com
The lung possesses specific transport systems that intra- and extracellularly maintain salt
and fluid balance necessary for its function. At birth, the lungs rapidly transform into a fluid (Na …

Conditioned media from mesenchymal stromal cells restore sodium transport and preserve epithelial permeability in an in vitro model of acute alveolar injury

A Goolaerts, N Pellan-Randrianarison… - … of Physiology-Lung …, 2014 - journals.physiology.org
Mesenchymal stromal cells (MSCs) or their media (MSC-M) were reported to reverse acute
lung injury (ALI)-induced decrease of alveolar fluid clearance. To determine the mechanisms …

[HTML][HTML] Hypoxia and β2-agonists regulate cell surface expression of the epithelial sodium channel in native alveolar epithelial cells

C Planès, M Blot-Chabaud, MA Matthay… - Journal of Biological …, 2002 - ASBMB
Alveolar hypoxia may impair sodium-dependent alveolar fluid transport and induce pulmonary
edema in rat and human lung, an effect that can be prevented by the inhalation of β 2 -…

[HTML][HTML] HIF-1α triggers ER stress and CHOP-mediated apoptosis in alveolar epithelial cells, a key event in pulmonary fibrosis

E Delbrel, A Soumare, A Naguez, R Label, O Bernard… - Scientific reports, 2018 - nature.com
Endoplasmic Reticulum (ER) stress of alveolar epithelial cells (AECs) is recognized as a key
event of cell dysfunction in pulmonary fibrosis (PF). However, the mechanisms leading to …

Hypoxia upregulates activity and expression of the glucose transporter GLUT1 in alveolar epithelial cells

A Ouiddir, C Planès, I Fernandes… - American journal of …, 1999 - atsjournals.org
Alveolar epithelial cells (AEC) are directly exposed to high alveolar O 2 tension. Many
pulmonary disorders are associated with a decrease in alveolar O 2 tension and AEC need to …

Hypoxia upregulates VEGF expression in alveolar epithelial cells in vitro and in vivo

I Pham, T Uchida, C Planes, LB Ware… - … of Physiology-Lung …, 2002 - journals.physiology.org
We investigated regulation of vascular endothelial growth factor (VEGF) expression by
hypoxia in cultured and freshly isolated rat alveolar epithelial cells (AEC). In vitro, hypoxia …

Hypoxia downregulates expression and activity of epithelial sodium channels in rat alveolar epithelial cells

C Planes, B Escoubet, M Blot-Chabaud… - American journal of …, 1997 - atsjournals.org
Decrease in alveolar oxygen tension may induce acute lung injury with pulmonary edema.
We investigated whether, in alveolar epithelial cells, expression and activity of epithelial …

[HTML][HTML] Defective ENaC processing and function in tissue kallikrein-deficient mice

N Picard, D Eladari, S El Moghrabi, C Planes… - Journal of biological …, 2008 - ASBMB
An inverse relationship exists between urinary tissue kallikrein (TK) excretion and blood
pressure in humans and rodents. In the kidney TK is synthesized in large amounts in the …