Metabolic reprogramming is a common hallmark of cancer, but a large variability in tumor
bioenergetics exists between patients. Using high-resolution respirometry on fresh biopsies of …

KRAS mutations are the most frequent molecular abnormalities found in one out of four
nonsmall cell lung cancers (NSCLC). Their incidence increases in cases of adenocarcinoma, …

Mutational signatures accumulate in somatic cells as an admixture of endogenous and
exogenous processes that occur during an individual’s lifetime. Since dividing cells release cell-…

Biological activities of vascular endothelial growth factor (VEGF) have been studied extensively
in endothelial cells (ECs), but few data are available regarding its effects on pericytes. In …

Immune checkpoints inhibitors (ICIs) have been a breakthrough, with unique response and
survival patterns compared with chemotherapy for patients with advanced Mismatch Repair-…

In patients with hepatocellular carcinoma (HCC) receiving sorafenib, drug resistance is
common. HCC develops in a microenvironment enriched with extracellular matrix proteins …

Hydrogels that are non-toxic, easy to use, cytocompatible, injectable and degradable are
valuable biomaterials for tissue engineering and tissue repair. However, few compounds …

Immune checkpoint inhibition is a new therapeutic strategy that has shown promising
efficacy in many cancer types. Significant activity associated with mismatch repair (MMR) …

Internal tandem duplication in Fms-like tyrosine kinase 3 (FLT3-ITD) is the most frequent
mutation observed in acute myeloid leukemia (AML) and correlates with poor prognosis. FLT3 …

Aim Interleukin (IL)-17 pathway is being clinically targeted in immune-mediated diseases,
most of which are associated with a significant cardiovascular risk. We investigated the …