The role of cytokines including interleukin-6 in COVID-19 induced pneumonia and macrophage activation syndrome-like disease

D McGonagle, K Sharif, A O'Regan, C Bridgewood - Autoimmunity reviews, 2020 - Elsevier
Severe COVID-19 associated pneumonia patients may exhibit features of systemic hyper-inflammation
designated under the umbrella term of macrophage activation syndrome (MAS) …

[HTML][HTML] Osteopontin as a means to cope with environmental insults: regulation of inflammation, tissue remodeling, and cell survival

DT Denhardt, M Noda, AW O'Regan… - The Journal of …, 2001 - Am Soc Clin Investig
Some features of the OPN protein. Indicated sites of O-glycosylation and phosphorylation
are intended to be representative; both vary (phosphorylation in particular) with the source of …

Osteopontin: a key cytokine in cell‐mediated and granulomatous inflammation

A O'Regan, JS Berman - International journal of experimental …, 2000 - Wiley Online Library
Osteopontin (Opn) is a secreted adhesive, glycosylated phosphoprotein that contains the
arginine‐glycine‐aspartic acid (RGD) cell‐binding sequence that is found in many extracellular …

Osteopontin is associated with T cells in sarcoid granulomas and has T cell adhesive and cytokine-like properties in vitro

AW O'Regan, GL Chupp, JA Lowry… - The Journal of …, 1999 - journals.aai.org
Sarcoidosis is a systemic disease characterized by the accumulation of activated T cells and
widespread granuloma formation. In addition, individual genetic predisposition appears to …

Tracheobronchial amyloidosis: the Boston University experience from 1984 to 1999

A O'Regan, HM Fenlon, JF Beamis Jr, MP Steele… - Medicine, 2000 - journals.lww.com
Amyloid is composed of B-pleated sheets of insoluble proteins that are deposited in various
Organs (14). In primary systemic amyloidosis, clonally ex-panded plasma cells residing in …

[HTML][HTML] Updated guidance on the management of COVID-19: from an American Thoracic Society/European Respiratory Society coordinated international task force …

…, RA Oeckler, I Ojanguren, A O'Regan… - European …, 2020 - Eur Respiratory Soc
Background Coronavirus disease 2019 (COVID-19) is a disease caused by severe acute
respiratory syndrome-coronavirus-2. Consensus suggestions can standardise care, thereby …

[HTML][HTML] Osteopontin (Eta-1) in cell-mediated immunity: teaching an old dog new tricks

AW O'Regan, GJ Nau, GL Chupp, JS Berman - Immunology today, 2000 - cell.com
Previously regarded as an adhesive bone matrix protein, recent studies suggest that
osteopontin (Eta-1) is also a novel RGD-containing cytokine that regulates early cell-mediated …

The role of osteopontin in lung disease

A O'Regan - Cytokine & growth factor reviews, 2003 - Elsevier
Osteopontin (Opn) is a multifunctional protein independently discovered by investigators from
diverse scientific backgrounds and implicated in a broad array of pathological processes. …

Pulmonary and tracheobronchial amyloidosis

JL Berk, A O'Regan, M Skinner - Seminars in respiratory and …, 2002 - thieme-connect.com
Amyloidosis is a collection of diseases in which different proteins are deposited as insoluble
β-pleated sheets, disrupting organ function. Each precursor protein induces a separate …

Osteopontin augments CD3-mediated interferon-γ and CD40 ligand expression by T cells, which results in IL-12 production from peripheral blood mononuclear cells

AW O'Regan, JM Hayden… - Journal of Leukocyte …, 2000 - academic.oup.com
Osteopontin is an RGD-containing bone matrix protein with cytokine-like functions that is
associated with early stages of Th1-mediated diseases. Although the function of osteopontin in …