Now that it is generally accepted that asthma is a heterogeneous condition, phenotyping of
asthma patients has become a mandatory part of the diagnostic workup of all patients who do …

Asthma and COPD are prevalent chronic inflammatory airway diseases that are responsible
for a large global disease burden. Both diseases are complex and heterogeneous, and they …

Whereas several factors have been implicated as being important in the development of fixed
airway obstruction in asthma, we are just beginning to explore the different components of …

Background Interleukin-5 (IL-5) is essential for the formation of eosinophils, which are thought
to have a major role in the pathogenesis of asthma and other allergic diseases. We aimed …

Background Mepolizumab, an anti-interleukin-5 monoclonal antibody approved as add-on
therapy to standard of care for patients with severe eosinophilic asthma, has been shown in …

Persistent airflow limitation can develop in nonsmoking patients with asthma. However, the
prevalence and risk factors for airways obstruction with incomplete reversibility in asthma are …

Background: Chronic rhinosinusitis and asthma are conditions that frequently coexist,
particularly in severe asthma. The precise mechanism of the relationship between upper and …

It has been suggested that patients with refractory eosinophilic airway inflammation represent
a separate “eosinophilic” asthma phenotype associated with increased morbidity and a …

Background Some patients with adult-onset asthma have severe disease, whereas others
have mild transient disease. It is currently unknown whether patients with severe adult-onset …

Background Patients with severe eosinophilic asthma show different responses to various
anti–IL-5 biologics, ranging from super response to nonresponse. Residual disease …