Pulmonary vascular and cardiac impairment in interstitial lung disease

M Panagiotou, AC Church, MK Johnson… - European …, 2017 - Eur Respiratory Soc
Pulmonary vascular and cardiac impairment is increasingly appreciated as a major adverse
factor in the natural history of interstitial lung disease. This clinically orientated review …

The CRASH report: emergency management dilemmas facing acute physicians in patients with pulmonary arterial hypertension

…, R Davies, M Toshner, J Pepke-Zaba, AC Church… - Thorax, 2017 - thorax.bmj.com
Treatment of acute emergencies in patients with pulmonary arterial hypertension (PAH) can
be challenging. In the UK and Ireland, management of adult patients with PAH is centred in …

Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate

…, C Cooper, AC Church, K Suhre, C Gieger… - …, 2015 - Am Heart Assoc
High blood pressure is a major contributor to the global burden of disease and discovering
novel causal pathways of blood pressure regulation has been challenging. We tested blood …

The reversal of pulmonary vascular remodeling through inhibition of p38 MAPK-alpha: a potential novel anti-inflammatory strategy in pulmonary hypertension

AC Church, DH Martin, R Wadsworth… - … of Physiology-Lung …, 2015 - journals.physiology.org
The p38 mitogen-activated protein kinase (MAPK) system is increasingly recognized as an
important inflammatory pathway in systemic vascular disease but its role in pulmonary …

Severe pulmonary hypertension in lung disease: phenotypes and response to treatment

MJ Brewis, AC Church, MK Johnson… - European Respiratory …, 2015 - Eur Respiratory Soc
Pulmonary hypertension (PH) due to lung disease (World Health Organization (WHO) group
3) is common, but severe PH, arbitrarily defined as mean pulmonary artery pressure ≥35 …

Mediastinal abscess after lung transplantation secondary to Burkholderia gladioli infection

AC Church, P Sivasothy, J Parmer… - The Journal of heart and …, 2009 - Elsevier
Burkholderia gladioli is an unusual organism that has become increasingly responsible for
infections in patients who are immunosuppressed, including patients who have undergone …

BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults

…, M Elliott, D Kennedy, C Gelder, A Glossop, AC Church… - Thorax, 2016 - thorax.bmj.com
Background The British Thoracic Society (BTS) published the guideline,‘The use of non-invasive
ventilation in acute respiratory failure’, in 2002. 1 This was in response to trials …

Validation of impedance cardiography in pulmonary arterial hypertension

…, N Mcglinchey, JS Baker, AC Church… - Clinical Physiology …, 2018 - Wiley Online Library
Background Non‐invasive methods of measuring cardiac output are highly desirable in
pulmonary arterial hypertension (PAH). We therefore sought to validate impedance cardiography …

Non‐invasive stroke volume measurement by cardiac magnetic resonance imaging and inert gas rebreathing in pulmonary hypertension

…, A Brown, WN Lee, AC Church… - Clinical physiology …, 2011 - Wiley Online Library
Objective: Right ventricular function determines the prognosis of pulmonary hypertension (PAH).
Measurement of stroke volume (SV) non‐invasively could be a promising method to …

BTS Clinical Statement on air travel for passengers with respiratory disease

RK Coker, A Armstrong, AC Church, S Holmes… - Thorax, 2022 - thorax.bmj.com
BTS recommendations for managing passengers with stable respiratory disease planning
air travel were published in Thorax in 2011. 1 This followed original guidance published in …