A Phase I study was conducted of 5-fluorouracil administered ip in a 2-liter volume of 1.5%
Inpersol. The drug was administered via Tenckhoff peritoneal dialysis catheters to ten …

Clara cells, progenitors for bronchiolar epithelium, are also primary targets for metabolically
activated pulmonary cytotoxicants and have an abundance of the cytochrome P-450 …

The toxicity of naphthalene and its metabolites has been investigated in vitro. Both
naphthalene and its metabolite 1-naphthol were bioactivated by human hepatic microsomes to …

Glutathione (GSH) and glutathione disulfide (GSSG) are biologically important intracellular
thiols; alterations in the GSH/GSSG ratio are often used to assess exposure of cells to …

Deficiency of the frataxin mRNA alters the transcriptome, triggering neuro- and cardiodegeneration
in Friedreich's ataxia. We microarrayed murine frataxin-deficient heart tissue, liver …

Intraperitoneal administration of the volatile hydrocarbon, naphthalene, resulted in severe
bronchiolar epithelial cell necrosis in mice, while hepatic or renal necrosis was not observed. …

To establish whether allergic asthma could be induced experimentally in a nonhuman primate
using a common human allergen, three female rhesus monkeys (Macaca mulatta) were …

Asthma is a worldwide health problem that affects 300 million people, as estimated by the
World Health Organization. A key question in light of this statistic is: “what is the most …

… Bars are arranged in order of decreasing average spot … Bars are arranged in order of
decreasing average spot volume. … Bars are arranged in order of decreasing average spot volume. …

Despite their substantially lower levels relative to hepatic tissue, pulmonary cytochrome P-450
(CYP) monooxygenases play an important role in the metabolic activation of substrates …