The purpose of this study was to illustrate high-resolution computed tomography (HRCT) findings in symptomatic adult Gaucher's disease patients. Five adult patients with Gaucher's disease experienced dyspnea. These patient were first evaluated by chest X-ray (CXR) followed by HRCT. The chest X-ray on one patient demonstrated a calcified granuloma. Two patients had interstitial disease only seen on HRCT, and two patients had a combination of interstitial and alveolar disease giving a mosaic pattern better illustrated on HRCT. HRCT can be used following CXR to evaluate lung pathology in symptomatic adult Gaucher's disease patients.