Ile50Val variant of IL4R alpha upregulates IgE synthesis and associates with atopic asthma

Nat Genet. 1998 Jun;19(2):119-20. doi: 10.1038/472.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Substitution
  • Animals
  • Asthma / complications
  • Asthma / immunology*
  • Humans
  • Hypersensitivity / complications
  • Hypersensitivity / immunology
  • Immunoglobulin E / biosynthesis*
  • Isoleucine / genetics
  • Isoleucine / immunology*
  • Mice
  • Mice, Inbred BALB C
  • Receptors, Interleukin-4 / genetics
  • Receptors, Interleukin-4 / immunology*
  • Up-Regulation*
  • Valine / genetics
  • Valine / immunology*

Substances

  • Receptors, Interleukin-4
  • Isoleucine
  • Immunoglobulin E
  • Valine