Abstract
Ipratropium bromide (0.5 mg) and fenoterol (2 mg) produced equivalent peak bronchodilatation between 1 and 2 h after administration to eight patients with chronic partially reversible airways obstruction. The duration of action compared with saline was 6 h for ipratropium and 4 h for fenoterol. Both drugs in combination produced greater bronchodilatation than either drug alone. The increase in FVC was disproportionately greater than FEV1 with both drugs and saline, suggesting relief of obstruction of small airways.
Publication types
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Clinical Trial
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Randomized Controlled Trial
MeSH terms
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Aerosols
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Aged
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Atropine Derivatives / administration & dosage*
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Ethanolamines / administration & dosage*
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Fenoterol / administration & dosage*
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Fenoterol / therapeutic use
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Forced Expiratory Volume
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Humans
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Ipratropium / administration & dosage*
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Ipratropium / therapeutic use
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Lung Diseases, Obstructive / drug therapy
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Lung Diseases, Obstructive / physiopathology
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Male
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Middle Aged
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Solutions
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Vital Capacity
Substances
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Aerosols
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Atropine Derivatives
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Ethanolamines
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Solutions
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Fenoterol
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Ipratropium