Abstract
Rackemann described the 'intrinsic asthma' population over 50 years ago as a unique subgroup that was characterized by onset of progressive loss of lung function beginning later in life, possibly after a respiratory infection. It has also been associated with a female predominance, aspirin-sensitive bronchospasm, and nasal polyposis. While the aetiology is not understood, we propose that persistent respiratory infections play a central role in the development of intrinsic asthma.
MeSH terms
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
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Aspirin / adverse effects
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Aspirin / therapeutic use
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Asthma / etiology*
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Asthma / immunology
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Asthma / physiopathology
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Bronchial Spasm / etiology
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Bronchial Spasm / immunology
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Bronchial Spasm / physiopathology
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Female
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Humans
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Lung / immunology
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Lung / physiopathology
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Male
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Nasal Polyps / complications
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Nasal Polyps / immunology
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Nasal Polyps / physiopathology
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Respiratory Tract Infections / complications*
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Respiratory Tract Infections / immunology
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Respiratory Tract Infections / physiopathology
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Sex Factors
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Aspirin