Abstract
Novel targeted treatment of non-small cell lung cancer (NSCLC) requires accurate classification of NSCLC as squamous cell carcinoma (SCC) and adenocarcinoma (AC). This study details the CK5/6 and TTF-1 immunoprofile of surgical resections of 45 NSCLCs (24 ACs and 21 SCCs) in tissue microarrays. All SCCs were CK5/6 positive, TTF-1 negative. 20 of 24 adenocarcinomas had the reverse pattern. In conclusion, all SCCs in this study were CK5/6 positive and TTF-1 negative, and therefore tumours that do not display this phenotype are unlikely to be SCCs. CK5/6 and TTF-1 is therefore a practical panel for the distinction between pulmonary SCC from AC in routine histopathology practice.
MeSH terms
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Adenocarcinoma / chemistry*
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Adenocarcinoma / classification
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Adenocarcinoma / diagnosis
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Biomarkers, Tumor / analysis
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Carcinoma, Non-Small-Cell Lung / chemistry*
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Carcinoma, Non-Small-Cell Lung / classification
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Carcinoma, Non-Small-Cell Lung / diagnosis
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Carcinoma, Squamous Cell / chemistry*
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Carcinoma, Squamous Cell / classification
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Carcinoma, Squamous Cell / diagnosis
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DNA-Binding Proteins / analysis*
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DNA-Binding Proteins / immunology
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Humans
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Immunohistochemistry
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Keratins / analysis
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Keratins / immunology
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Lung Neoplasms / chemistry*
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Lung Neoplasms / classification
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Lung Neoplasms / diagnosis
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Tissue Array Analysis
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Transcription Factors
Substances
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Biomarkers, Tumor
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DNA-Binding Proteins
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TTF1 protein, human
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Transcription Factors
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Keratins