Elevated serum surfactant protein A and D in pulmonary alveolar microlithiasis

Hiroki Takahashi; Hirofumi Chiba; Masanori Shiratori; Teruo Tachibana; Shosaku Abe

doi:10.1111/j.1440-1843.2006.00844.x

Elevated serum surfactant protein A and D in pulmonary alveolar microlithiasis

Respirology. 2006 May;11(3):330-3. doi: 10.1111/j.1440-1843.2006.00844.x.

Authors

Hiroki Takahashi¹, Hirofumi Chiba, Masanori Shiratori, Teruo Tachibana, Shosaku Abe

Affiliation

¹ The Third Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, Japan.

PMID: 16635094
DOI: 10.1111/j.1440-1843.2006.00844.x

Abstract

Pulmonary alveolar microlithiasis (PAM) is a rare disease characterized by widespread localization of calcispherites in the alveolar spaces. The authors report two cases of PAM, with markedly elevated sera concentrations of surfactant protein-A and surfactant protein-D, which showed a tendency to increase as the disease progressed. Therefore, surfactant protein-A and surfactant protein-D may function as serum markers to monitor the disease activity and progression of PAM.

Publication types

Case Reports

MeSH terms

Aged, 80 and over
Biomarkers / blood
Biopsy
Diagnosis, Differential
Female
Humans
Lithiasis / blood*
Lithiasis / diagnostic imaging
Lithiasis / pathology
Lung Diseases / blood*
Lung Diseases / diagnostic imaging
Lung Diseases / pathology
Male
Middle Aged
Pulmonary Alveoli*
Pulmonary Surfactant-Associated Protein A / blood*
Pulmonary Surfactant-Associated Protein D / blood*
Tomography, X-Ray Computed

Substances

Biomarkers
Pulmonary Surfactant-Associated Protein A
Pulmonary Surfactant-Associated Protein D