[Pulmonary alveolar phospholipoproteinosis]

Philippe Delaval; Graziella Brinchault; Romain Corre; Stéphane Jouneau; Catherine Meunier; Eric Briens

doi:10.1016/s0761-8417(05)84811-4

[Pulmonary alveolar phospholipoproteinosis]

Rev Pneumol Clin. 2005 Jun;61(3):186-92. doi: 10.1016/s0761-8417(05)84811-4.

[Article in French]

Authors

Philippe Delaval¹, Graziella Brinchault, Romain Corre, Stéphane Jouneau, Catherine Meunier, Eric Briens

Affiliation

¹ Service de Pneumologie, Centre Cardio-Pneumologique, Hôpital Pontchaillou, CHU, 35033 Rennes Cedex. philippe.delaval@chu-rennes.fr

PMID: 16142192
DOI: 10.1016/s0761-8417(05)84811-4

Abstract

Pulmonary alveolar phospholipoproteinosis is a rare lung disease of unknown cause characterized by surfactant plugging of the alveoli. At the present time, surgical lung biopsy, long considered as the gold standard, is not necessary for positive diagnosis of pulmonary alveolar phospholipoproteinosis when computed tomography anomalies and analysis of bronchial lavage fluids present a typical pattern. Treatment requires abundant lavage, but the demonstration of anti-GM-CSF antibodies in primary forms opens new therapeutic perspectives.

Publication types

Review

MeSH terms

Antibodies / therapeutic use
Bronchoalveolar Lavage
Granulocyte-Macrophage Colony-Stimulating Factor / immunology
Humans
Lipoproteins / metabolism*
Phospholipids / metabolism*
Pulmonary Alveolar Proteinosis / diagnosis*
Pulmonary Alveolar Proteinosis / diagnostic imaging
Pulmonary Alveolar Proteinosis / metabolism
Pulmonary Alveolar Proteinosis / therapy
Pulmonary Surfactants / metabolism*
Tomography, X-Ray Computed

Substances

Antibodies
Lipoproteins
Phospholipids
Pulmonary Surfactants
Granulocyte-Macrophage Colony-Stimulating Factor