Abstract
In the battle against infections with mycobacteria, the body employs components of both the innate and adaptive arms of the immune system. Toll-like receptors (TLRs) mediate the activation of cells of the innate immune system leading to dynamic functions including direct anti-microbial activity, induction of cytokine secretion, triggering dendritic cell maturation, and triggering apoptosis. Furthermore, TLR activation is capable of modulating the adaptive immune response with a bias towards a Th1 T-cell response. However, the activation of TLRs by mycobacteria may also provide a means of immune evasion. Therefore, the modulation of TLR activation can influence the ability to properly destroy invading pathogens such as mycobacteria.
MeSH terms
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Animals
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Cytokines / immunology
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Cytokines / physiology
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Dendritic Cells / immunology
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Dendritic Cells / physiology
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Gene Expression Regulation
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Humans
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Immune Tolerance / immunology
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Immune Tolerance / physiology
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Immunity, Cellular / immunology
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Immunity, Innate / immunology
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Ligands
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Lymphocyte Activation / immunology
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Macrophages / immunology
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Macrophages / physiology
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Macrophages, Alveolar / chemistry
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Macrophages, Alveolar / immunology
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / immunology*
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Membrane Glycoproteins / physiology
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Mice
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Mice, Inbred C3H
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Models, Immunological
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Mycobacterium Infections / immunology*
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Polymorphism, Single Nucleotide
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / immunology*
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Receptors, Cell Surface / physiology
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Skin / chemistry
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Skin / cytology
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T-Lymphocytes / immunology
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T-Lymphocytes / physiology
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Th1 Cells / immunology
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Th1 Cells / physiology
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Toll-Like Receptors
Substances
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Cytokines
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Ligands
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Membrane Glycoproteins
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Receptors, Cell Surface
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Toll-Like Receptors