B-Cell Lymphoma Associated with Sjögren's Syndrome among Japanese Patients : A Clinicopathologic and Immunohistochemical Study of 15 Cases

Masaru Kojima; Norihumi Tsukamoto; Akihiko Yokohama; Yoshiyuki Suzuki; Kazuhiko Shimizu; Masahumi Nishikawa; Kayoko Murayama; Tomomi Miyanaga; Atsushi Isoda; Ken Shimizu; Hideaki Itoh; Nobuhide Masawa; Katsue Yoshida; Hiroshi Inagaki

doi:10.3960/jslrt.49.89

Original Article

B-Cell Lymphoma Associated with Sjögren's Syndrome among Japanese Patients : A Clinicopathologic and Immunohistochemical Study of 15 Cases

Masaru Kojima, Norihumi Tsukamoto, Akihiko Yokohama, Yoshiyuki Suzuki, Kazuhiko Shimizu, Masahumi Nishikawa, Kayoko Murayama, Tomomi Miyanaga, Atsushi Isoda, Ken Shimizu, Hideaki Itoh, Nobuhide Masawa, Katsue Yoshida, Hiroshi Inagaki

Author information

Masaru Kojima
Department of Anatomic Diagnostic Pathology, Dokkyo University School of Medicine
Norihumi Tsukamoto
Department of Medicine and Clinical Science, Gunma University School of Medicine
Akihiko Yokohama
Department of Medicine and Clinical Science, Gunma University School of Medicine
Yoshiyuki Suzuki
Department of Radiation Oncology, Gunma University, Graduate School of Medicine
Kazuhiko Shimizu
Department of Pathology and Clinical Laboratories, Ashikaga Red Cross Hospital
Masahumi Nishikawa
Department of Pathology and Clinical Laboratories, National Tochigi Hospital
Kayoko Murayama
Department of Hematological oncology, Gunma Cancer Center Hospital, Ohta, Japan. Gunma Cancer Center Hospital
Tomomi Miyanaga
Devision of Pathology, Gunma University School of Medicine
Atsushi Isoda
Department of Hematology, National Nishigunma Hospital
Ken Shimizu
Department of Pathology Saitama Social Insurance Hospital
Hideaki Itoh
Department Pathology and Clinical Laboratories, Maebashi Red Cross Hospital
Nobuhide Masawa
Department of Anatomic Diagnostic Pathology, Dokkyo University School of Medicine
Katsue Yoshida
Department of Pathology and Clinical Laboratories, Kiryu Welfare General Hospital
Hiroshi Inagaki
Department of Pathology, Nagoya City University Graduate School of Medical Science

Keywords: B-cell lymphoma, Sjögren's syndrome, clinicopathologic findings, mucosa-associated lymphoid tissue lymphoma

JOURNAL FREE ACCESS

2009 Volume 49 Issue 2 Pages 89-95

DOI https://doi.org/10.3960/jslrt.49.89

Details

Abstract

To clarify the clinicopathological findings of B-cell lymphoma associated with Sjögren's syndrome (SJS) among Japanese Patients, 15 individuals with this disease were studied. The patients, 14 females and one male, ranged in age from 41 to 73 years with a median age of 56 years. These lymphomas arose not only in the salivary gland (n=4) but also in other mucosal extranodal sites (n=5). Histologically, six cases were marginal zone B-cell lymphoma (MZBL) of the mucosa-associated lymphoid tissue (MALT) type, three cases were diffuse large B-cell lymphoma (DLBCL) + MALT type lymphoma, two cases were nodal MZBL and one case each was small lymphocytic lymphoma, Burkitt's lymphoma, CD10⁺ DLBCL and DLBCL + nodal MZBL. Using in situ hybridization, numerous Epstein-Barr virus⁺ tumor cells were detected only in the case of Burkitt lymphoma. There were no human-herpes type 8⁺ tumor cells in any of the 15 cases. There was no API2-MALT1 fusion transcript in any of the eight cases examined. B-cell lymphoma associated with SJS also frequently affected extranodal organs in patients from Japan as well as from patients in Western countries. The majority of B-cell lymphomas in patients with SJS also appear to be low-grade MZBLs or high-grade lymphomas probably derived from MZBL both in Western countries and in Japan. [J Clin Exp Hematopathol 49(2) : 89-95, 2009]

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