Elsevier

Translational Oncology

Volume 6, Issue 3, June 2013, Pages 319-328, IN6-IN8
Translational Oncology

Circulating Cell-Free DNA from Colorectal Cancer Patients May Reveal High KRAS or BRAF Mutation Load

https://doi.org/10.1593/tlo.12445Get rights and content
Under a Creative Commons license
open access

Abstract

Our data might suggest a very high variation in the proportion of malignant cells in colorectal tumors and/or low tumor cell clonogenicity. However, the direct relationship between these data and the proportion of malignant cells is currently uncertain as the mechanism of ccfDNA release determines the yield (necrosis, apoptosis, or active release). Therefore, interindividual comparison of the proportion of mutant allele determined from circulating DNA could appear somewhat more difficult to interpret; however, this parameter could be an efficient biomarker for monitoring or following up CRC patients and could be combined with size fraction analysis, as demonstrated in this study, to provide a deeper examination toward this goal.

Cited by (0)

This article refers to supplementary materials, which are designated by Tables W1 to W3 and Figures W1 and W2 and are available online at www.transonc.com